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题名: Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection
作者: Han, FT;  Huynh, BH;  Shi, HL;  Lin, BC;  Ma, YF
刊名: ANALYTICAL CHEMISTRY
发表日期: 1999-04-01
卷: 71, 期:7, 页:1265-1269
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Pteridines are a class of compounds excreted in urine, the levels of which are found to elevate significantly in tumor-related diseases. For the first time, we have developed a method, based on high-performance capillary electrophoresis (HPCE) and laser-induced fluorescence (LIF)-detection, to monitor the pteridine levels in urine. HPCE provides better separation than high-performance liquid chromatography and the LIF detector enables us to detect minute amounts of pteridines in body fluid, Eight different pteridine derivatives were well separated in 0.1 M Tris-0.1 M borate-2 mM EDTA buffer (pH 8.75) using a 60-cm fused-silica capillary (50-mu m i.d., 35-cm effective length), six of which were detected and characterized in urine samples from normal persons and different cancer patients. The detection Emits of these pteridines are under 1 x 10(-10) M. The levels of neopterint pterine, xanthopterin, and pterin-6-carboxylic acid were found to be significantly elevated in urine excreted by cancer patents, while the level of isoxanthopterin dropped in these patients. No significant change of biopterin level was found between healthy individuals and cancer patients. This method can be used in clinical laboratories either for cancer monitoring or for precancer screening.
关键词[WOS]: NEOPTERIN ;  EXCRETION ;  BIOPTERIN ;  CANCER
语种: 英语
WOS记录号: WOS:000079593900014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138553
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Truman State Univ, Div Sci, Kirksville, MO 63501 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Han, FT,Huynh, BH,Shi, HL,et al. Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection[J]. ANALYTICAL CHEMISTRY,1999,71(7):1265-1269.
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