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题名: Enantiomeric separation of amino acid derivatives by ion-pair chromatography
作者: Li, HY;  Liang, XM;  Xue, XY
关键词: ion-pair chromatography ;  a chiral ion-pairing reagent ;  chiral stationary phase ;  retention ;  enantioselectivity
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 1999-05-01
卷: 27, 期:5, 页:523-527
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: The enantiomeric separation of N-3,5-dinitrtobenzoyl (DNB) of amino acid derivatives by ion-pair chromatography with a chiral stationary phase (CSP), derived from (S)-N-(2-naphthyl)-alanine has been examined. It was found that the increase in the concentration of a chiral ion-pair reagent caused significant increase in the capacity factors of both enantiomers of DNB-phenylglycine and DNB-leucine until a limiting value is reached, while the enantioselectivities of both analytes remained unchanged. A mobile phase of methanol-aqueous phosphate buffer was used. It was found that the concentration of methanol in the mobile phase dramatically affected the retention of the enantiomers. A minimum in enantioselectivity occurred at about 60% methanol. In addition, the separations of the enantiomers of the same analytes on a (R)-N-( 2-naphthyl)-alanine-derived CSP was studied. It was indicated that two columns of opposite chirality gave reversed elution orders.
关键词[WOS]: DRUGS
语种: 英语
WOS记录号: WOS:000080566400006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138590
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
2.Dalian Univ Technol, Coll Chem Engn, Dalian 116012, Peoples R China

Recommended Citation:
Li, HY,Liang, XM,Xue, XY. Enantiomeric separation of amino acid derivatives by ion-pair chromatography[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,1999,27(5):523-527.
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