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题名: Enantiomer separation by CEC - Enantiomer separation by packed-capillary electrochromatography
作者: Zhu, J;  Zou, HF;  Shi, W;  Rui, JZ;  Ni, JY;  Zhang, YK
关键词: packed-capillary electrochromatography ;  enantiomer separation ;  chiral sector ;  fast analysis ;  high efficiency ;  resolution
刊名: SCIENCE IN CHINA SERIES B-CHEMISTRY
发表日期: 1999-10-01
卷: 42, 期:5, 页:511-519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Three chiral compounds were successfully separated in a shea time with two enantiomer separation models on packed-capillary electrochromatograpy ( CEC). (i) 75 mu m I.D. capillaries were packed with 5 mu m beta-cyclodextrin (beta-CD) chiral stationary phase (CSP). Effects of voltage, pH and concentration of organic modifier on electroosmotic now (EOF) and chiral separations were investigated systematically. Enantiomers of a neutral compound (benzoin) and a neutral drug (mephenytoin) were separated within a shea time with high efficiency. Efficiency of 32000 theoretical plates per meter and resolution (R-s) of 1.42 were achieved for enantiomers of benzoin using a beta CD packed column with 6.2 cm packed length. Efficiency of 45000 theoretical plates per meter and R-2 of 3.40 were obtained for enantiomers of mephenytoin. Especially, the enantiomer separation of mephenytion was performed in just 3.4 min with R-s of 2.60. (ii) 75 mu m I.D, capillary was packed with octadecylsilica particles (ODS). Chiral separation of a basic drug, propranolol, was studied with chiral agent, via addition of the dimethyl-beta-cyclodextrin (DM beta-CD) directly into the mobile phase on this column. Baseline separation and efficiency of 81000 theoretical plates per meter were achieved for propranolol.
关键词[WOS]: LIQUID-CHROMATOGRAPHY ;  ELECTROPHORESIS
语种: 英语
WOS记录号: WOS:000083316000009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138602
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Zhu, J,Zou, HF,Shi, W,et al. Enantiomer separation by CEC - Enantiomer separation by packed-capillary electrochromatography[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,1999,42(5):511-519.
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