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Enantiomer separation by CEC - Enantiomer separation by packed-capillary electrochromatography
Zhu, J; Zou, HF; Shi, W; Rui, JZ; Ni, JY; Zhang, YK
关键词Packed-capillary Electrochromatography Enantiomer Separation Chiral Sector Fast Analysis High Efficiency Resolution
刊名SCIENCE IN CHINA SERIES B-CHEMISTRY
1999-10-01
42期:5页:511-519
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]LIQUID-CHROMATOGRAPHY ; ELECTROPHORESIS
英文摘要Three chiral compounds were successfully separated in a shea time with two enantiomer separation models on packed-capillary electrochromatograpy ( CEC). (i) 75 mu m I.D. capillaries were packed with 5 mu m beta-cyclodextrin (beta-CD) chiral stationary phase (CSP). Effects of voltage, pH and concentration of organic modifier on electroosmotic now (EOF) and chiral separations were investigated systematically. Enantiomers of a neutral compound (benzoin) and a neutral drug (mephenytoin) were separated within a shea time with high efficiency. Efficiency of 32000 theoretical plates per meter and resolution (R-s) of 1.42 were achieved for enantiomers of benzoin using a beta CD packed column with 6.2 cm packed length. Efficiency of 45000 theoretical plates per meter and R-2 of 3.40 were obtained for enantiomers of mephenytoin. Especially, the enantiomer separation of mephenytion was performed in just 3.4 min with R-s of 2.60. (ii) 75 mu m I.D, capillary was packed with octadecylsilica particles (ODS). Chiral separation of a basic drug, propranolol, was studied with chiral agent, via addition of the dimethyl-beta-cyclodextrin (DM beta-CD) directly into the mobile phase on this column. Baseline separation and efficiency of 81000 theoretical plates per meter were achieved for propranolol.
语种英语
WOS记录号WOS:000083316000009
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138602
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
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GB/T 7714
Zhu, J,Zou, HF,Shi, W,et al. Enantiomer separation by CEC - Enantiomer separation by packed-capillary electrochromatography[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,1999,42(5):511-519.
APA Zhu, J,Zou, HF,Shi, W,Rui, JZ,Ni, JY,&Zhang, YK.(1999).Enantiomer separation by CEC - Enantiomer separation by packed-capillary electrochromatography.SCIENCE IN CHINA SERIES B-CHEMISTRY,42(5),511-519.
MLA Zhu, J,et al."Enantiomer separation by CEC - Enantiomer separation by packed-capillary electrochromatography".SCIENCE IN CHINA SERIES B-CHEMISTRY 42.5(1999):511-519.
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