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题名: Separation of drugs by capillary electrophoresis, Part 10. Permethyl-alpha-cyclodextrin as chiral solvating agent
作者: Zhu, XF;  Lin, BC;  Jakob, A;  Wuerthner, S;  Koppenhoefer, B
关键词: drugs ;  capillary zone electrophoresis ;  cyclodextrin
刊名: ELECTROPHORESIS
发表日期: 1999-07-01
卷: 20, 期:9, 页:1878-1889
收录类别: ISTP ;  SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Following the German-Chinese Drug Screening Program, 86 racemic drugs were investigated in capillary zone electrophoresis in the presence of the chiral solvating agent (CSA) hexakis-(2,3,6-tri-O-methyl)-alpha-cyclodex (TM-alpha-CD). Of the 86 drugs, 23 were separated into enantiomeric pairs. A comparison of the migration separation factors (alpha(m)) and the migration retardation factors (R-m) with previously published data for native alpha-CD revealed that the 'upper-rim' hydroxyl groups do not necessarily facilitate the recognition of the drug enantiomers by the chiral host. In contrast, an overall increase in affinity for the permethylated host led to a higher rate of successful enantiomer separations. A key substructure (4H) was identified in the analyte structure domain, with a crucial influence on the behavior of a particular drug.
关键词[WOS]: HYDROXYPROPYL-BETA-CYCLODEXTRIN ;  ZONE ELECTROPHORESIS ;  GAMMA-CYCLODEXTRIN ;  BASIC DRUGS ;  ELECTROKINETIC CHROMATOGRAPHY ;  AMINO-ALCOHOLS ;  ENANTIOMERS ;  RESOLUTION ;  PARAMETERS ;  ADDITIVES
语种: 英语
WOS记录号: WOS:000081688800012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138649
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, D-72076 Tubingen, Germany
2.Acad Sinica, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Zhu, XF,Lin, BC,Jakob, A,et al. Separation of drugs by capillary electrophoresis, Part 10. Permethyl-alpha-cyclodextrin as chiral solvating agent[J]. ELECTROPHORESIS,1999,20(9):1878-1889.
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