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Optical resolution of alpha-alkyl phenyl acetonitriles by HPLC on cellulose triacetate chiral stationary phases coated on underivatized silica gel
Chen, XM; Zou, HF; Yang, LI; Wang, HL; Zhang, Q
关键词Coating Solvent Effect Organic Modifiers Mass Distribution Of Cellulose Chiral Recognition Mechanism Optical Resolution Alpha-alkyl Phenyl Acetonitriles
刊名CHIRALITY
2000
12期:8页:621-626
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; DERIVATIVES ; ENANTIOMERS ; TRIACETYLCELLULOSE ; RECOGNITION ; RETENTION ; MECHANISM
英文摘要Microcrystalline celluloses from two sources were used to prepare cellulose triacetate chiral stationary phases (CSPs) coated on underivatized silica gel, which shows discriminating chiral recognition for enantiomers. The chiral separation of four or-alkyl phenyl acetonitriles was investigated on the prepared CSPs. It was observed that the concentration of the coating solvent of phenol in dichloromethane plays an important role in the resolution of the solutes. A series of primary alcohols, including secondary and tertiary alcohols, were used as mobile phase modifiers to investigate the effect of the structures of these modifiers on the capacity factors (k') and the separation factors (alpha). Also, the effect of the concentration of alcohol on the capacity factors and separation factors was examined. The chiral recognition mechanism of alpha-alkyl phenyl acetonitriles on the prepared CSPs is discussed. (C) 2000 Wiley-Liss, Inc.
语种英语
WOS记录号WOS:000088277900004
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138728
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Natl Chromatograph R&D Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
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GB/T 7714
Chen, XM,Zou, HF,Yang, LI,et al. Optical resolution of alpha-alkyl phenyl acetonitriles by HPLC on cellulose triacetate chiral stationary phases coated on underivatized silica gel[J]. CHIRALITY,2000,12(8):621-626.
APA Chen, XM,Zou, HF,Yang, LI,Wang, HL,&Zhang, Q.(2000).Optical resolution of alpha-alkyl phenyl acetonitriles by HPLC on cellulose triacetate chiral stationary phases coated on underivatized silica gel.CHIRALITY,12(8),621-626.
MLA Chen, XM,et al."Optical resolution of alpha-alkyl phenyl acetonitriles by HPLC on cellulose triacetate chiral stationary phases coated on underivatized silica gel".CHIRALITY 12.8(2000):621-626.
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