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题名: Optical resolution of alpha-alkyl phenyl acetonitriles by HPLC on cellulose triacetate chiral stationary phases coated on underivatized silica gel
作者: Chen, XM;  Zou, HF;  Yang, LI;  Wang, HL;  Zhang, Q
关键词: coating solvent effect ;  organic modifiers ;  mass distribution of cellulose ;  chiral recognition mechanism ;  optical resolution ;  alpha-alkyl phenyl acetonitriles
刊名: CHIRALITY
发表日期: 2000
卷: 12, 期:8, 页:621-626
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Analytical ;  Chemistry, Organic ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: Microcrystalline celluloses from two sources were used to prepare cellulose triacetate chiral stationary phases (CSPs) coated on underivatized silica gel, which shows discriminating chiral recognition for enantiomers. The chiral separation of four or-alkyl phenyl acetonitriles was investigated on the prepared CSPs. It was observed that the concentration of the coating solvent of phenol in dichloromethane plays an important role in the resolution of the solutes. A series of primary alcohols, including secondary and tertiary alcohols, were used as mobile phase modifiers to investigate the effect of the structures of these modifiers on the capacity factors (k') and the separation factors (alpha). Also, the effect of the concentration of alcohol on the capacity factors and separation factors was examined. The chiral recognition mechanism of alpha-alkyl phenyl acetonitriles on the prepared CSPs is discussed. (C) 2000 Wiley-Liss, Inc.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  DERIVATIVES ;  ENANTIOMERS ;  TRIACETYLCELLULOSE ;  RECOGNITION ;  RETENTION ;  MECHANISM
语种: 英语
WOS记录号: WOS:000088277900004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138728
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Natl Chromatograph R&D Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Chen, XM,Zou, HF,Yang, LI,et al. Optical resolution of alpha-alkyl phenyl acetonitriles by HPLC on cellulose triacetate chiral stationary phases coated on underivatized silica gel[J]. CHIRALITY,2000,12(8):621-626.
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