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题名: Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector
作者: Li, GB;  Lin, XL;  Zhu, CF;  Wu, P
关键词: enantioseparation ;  chiral drugs ;  L-glutamine ;  capillary electrophoresis
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2000-10-01
卷: 28, 期:10, 页:1287-1290
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A rapid separation method using L-glutamine as chiral selector was set up. Ten kinds of racemates, such as propranolol, mexiletine, propafenone, eprajinone, isoprenaline, ketamine, anisodamine, lobeline, bupivacaine, benzhexol ect. were successfully separated by choosing the best separating conditions. The use of borax and L-glutamine as buffer additive was found to be effective for the chiral separation. The pH of the background electrolyte and the concentrations of chiral selector and borax were optimized. In a solution containing 60 mmol/L L-glutamine and 60 mmol/L borax (pH = 9.25), the ten drugs were baseline separated in less than 11 minutes. The separating mechanism was also discussed.
关键词[WOS]: ZONE-ELECTROPHORESIS ;  CYCLODEXTRIN ;  SEPARATION
语种: 英语
WOS记录号: WOS:000165083400025
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138746
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shandong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Li, GB,Lin, XL,Zhu, CF,et al. Enantioseparation of several pharmaceutical racemates with capillary electrophoresis using L-glutamine as the chiral selector[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2000,28(10):1287-1290.
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