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Studies on human breast cancer tissue with infrared spectrometry
Huo, H; Hu, X; Guan, HW; Wang, XF; Che, X; Huang, WD
关键词Infrared Spectrometry Breast Cancer Study On Tumor
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2000-08-01
21期:8页:1244-1247
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]TUNING FT-IR ; SPECTRA ; SPECTROSCOPY ; CELLS
英文摘要The normal, benign and malignant human breast tissues have been studied by means of infrared spectroscopy. Some remarkable spectral differences (shape, peak positions and relative intensities) are observed among these three types of the samples, In the malignant breast tissues, these mainly characteristic changes involve: (1) In comparison with the normal breast tissues, the band near 1 162 cm(-1) from the stretching modes of C-O(H) group in proteins evidently shifts to a higher wavenumber , which suggests that the intermolecular hydrogen bonds are almost broken; The band near 3 310 cm(-1) from the stretching modes of the hydrogen-bonded N-H in protein molecules shifts to a lower wavenumber, which indicates that the intensity of the hydrogen bonds on the NH ... O=C is stronger in protein molecules of malignant breast tissues. (2) The intensity of the symmetric stretching modes of v(PO2-) at 1 080 cm(-1) from the phosphodiester groups in cellular nucleic acids is remarkably stronger, which suggests that the relative contents of DNA in cancer cellular increase. The symmetric stretching modes of PO3- at 970 cm(-1) from the phosphorylated proteins become stronger, which suggests that the relative contents of phosphorylated protein increase, (3) The change of the intensity of collagen bands indicates the increase of its relative contents, This investigation shows that Infrared spectrometry can represent the characteristic of the breast tumor at the molecular level.
语种英语
WOS记录号WOS:000088950300022
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138760
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
2.Dalian Med Univ, Subsidiary Hosp 1, Dalian 116011, Peoples R China
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GB/T 7714
Huo, H,Hu, X,Guan, HW,et al. Studies on human breast cancer tissue with infrared spectrometry[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2000,21(8):1244-1247.
APA Huo, H,Hu, X,Guan, HW,Wang, XF,Che, X,&Huang, WD.(2000).Studies on human breast cancer tissue with infrared spectrometry.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,21(8),1244-1247.
MLA Huo, H,et al."Studies on human breast cancer tissue with infrared spectrometry".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 21.8(2000):1244-1247.
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