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题名: Studies on human breast cancer tissue with infrared spectrometry
作者: Huo, H;  Hu, X;  Guan, HW;  Wang, XF;  Che, X;  Huang, WD
关键词: infrared spectrometry ;  breast cancer ;  study on tumor
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2000-08-01
卷: 21, 期:8, 页:1244-1247
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The normal, benign and malignant human breast tissues have been studied by means of infrared spectroscopy. Some remarkable spectral differences (shape, peak positions and relative intensities) are observed among these three types of the samples, In the malignant breast tissues, these mainly characteristic changes involve: (1) In comparison with the normal breast tissues, the band near 1 162 cm(-1) from the stretching modes of C-O(H) group in proteins evidently shifts to a higher wavenumber , which suggests that the intermolecular hydrogen bonds are almost broken; The band near 3 310 cm(-1) from the stretching modes of the hydrogen-bonded N-H in protein molecules shifts to a lower wavenumber, which indicates that the intensity of the hydrogen bonds on the NH ... O=C is stronger in protein molecules of malignant breast tissues. (2) The intensity of the symmetric stretching modes of v(PO2-) at 1 080 cm(-1) from the phosphodiester groups in cellular nucleic acids is remarkably stronger, which suggests that the relative contents of DNA in cancer cellular increase. The symmetric stretching modes of PO3- at 970 cm(-1) from the phosphorylated proteins become stronger, which suggests that the relative contents of phosphorylated protein increase, (3) The change of the intensity of collagen bands indicates the increase of its relative contents, This investigation shows that Infrared spectrometry can represent the characteristic of the breast tumor at the molecular level.
关键词[WOS]: TUNING FT-IR ;  SPECTRA ;  SPECTROSCOPY ;  CELLS
语种: 英语
WOS记录号: WOS:000088950300022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138760
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
2.Dalian Med Univ, Subsidiary Hosp 1, Dalian 116011, Peoples R China

Recommended Citation:
Huo, H,Hu, X,Guan, HW,et al. Studies on human breast cancer tissue with infrared spectrometry[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2000,21(8):1244-1247.
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