DICP OpenIR
New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs
Li, GB; Lin, XL; Zhu, CF; Hao, AY; Guan, YF
KeywordCapillary Electrophoresis Enantiomer Separation Cyclodextrin Beta-cyclodextrin Derivative Chiral Drugs
Source PublicationANALYTICA CHIMICA ACTA
2000-09-21
Volume421Issue:1Pages:27-34
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordZONE-ELECTROPHORESIS ; CYCLOMALTOHEPTAOSE ; CHROMATOGRAPHY ; ETHER ; ACIDS
AbstractThe uncharged beta-cyclodextrin (beta-CD) derivative mono-3-O-phenylcarbamoyl-beta-CD was successfully used as chiral selector in capillary zone electrophoresis. Several chiral drugs such as propafenone and verapamil enantiomers belonging to different classes of compounds of pharmaceutical interest were resolved. The chiral resolution (Rs) was strongly influenced by the concentrations of the cyclodextrin derivative, the background electrolyte, and the pH of the background electrolyte. The influence of organic modifier was also studied. Under the conditions of 40 mmol/l berate buffer at pH 9.18 containing 2.5 mmol/l mono-3-phenylcarbamoyl-beta-CD, baseline separation (Rs=3.88 for verapamil, Rs=3.32 for propafenone) of the enantiomers can be achieved. (C) 2000 Elsevier Science B.V. All rights reserved.
Language英语
WOS IDWOS:000089308800004
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138787
Collection中国科学院大连化学物理研究所
Affiliation1.Shandong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China
2.Acad Sinica, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
Recommended Citation
GB/T 7714
Li, GB,Lin, XL,Zhu, CF,et al. New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs[J]. ANALYTICA CHIMICA ACTA,2000,421(1):27-34.
APA Li, GB,Lin, XL,Zhu, CF,Hao, AY,&Guan, YF.(2000).New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs.ANALYTICA CHIMICA ACTA,421(1),27-34.
MLA Li, GB,et al."New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs".ANALYTICA CHIMICA ACTA 421.1(2000):27-34.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, GB]'s Articles
[Lin, XL]'s Articles
[Zhu, CF]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, GB]'s Articles
[Lin, XL]'s Articles
[Zhu, CF]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, GB]'s Articles
[Lin, XL]'s Articles
[Zhu, CF]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.