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题名: New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs
作者: Li, GB;  Lin, XL;  Zhu, CF;  Hao, AY;  Guan, YF
关键词: capillary electrophoresis ;  enantiomer separation ;  cyclodextrin ;  beta-cyclodextrin derivative ;  chiral drugs
刊名: ANALYTICA CHIMICA ACTA
发表日期: 2000-09-21
卷: 421, 期:1, 页:27-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: The uncharged beta-cyclodextrin (beta-CD) derivative mono-3-O-phenylcarbamoyl-beta-CD was successfully used as chiral selector in capillary zone electrophoresis. Several chiral drugs such as propafenone and verapamil enantiomers belonging to different classes of compounds of pharmaceutical interest were resolved. The chiral resolution (Rs) was strongly influenced by the concentrations of the cyclodextrin derivative, the background electrolyte, and the pH of the background electrolyte. The influence of organic modifier was also studied. Under the conditions of 40 mmol/l berate buffer at pH 9.18 containing 2.5 mmol/l mono-3-phenylcarbamoyl-beta-CD, baseline separation (Rs=3.88 for verapamil, Rs=3.32 for propafenone) of the enantiomers can be achieved. (C) 2000 Elsevier Science B.V. All rights reserved.
关键词[WOS]: ZONE-ELECTROPHORESIS ;  CYCLOMALTOHEPTAOSE ;  CHROMATOGRAPHY ;  ETHER ;  ACIDS
语种: 英语
WOS记录号: WOS:000089308800004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138787
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shandong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China
2.Acad Sinica, Dalian Inst Chem Phys, Dalian 116012, Peoples R China

Recommended Citation:
Li, GB,Lin, XL,Zhu, CF,et al. New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs[J]. ANALYTICA CHIMICA ACTA,2000,421(1):27-34.
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