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New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs
Li, GB; Lin, XL; Zhu, CF; Hao, AY; Guan, YF
关键词Capillary Electrophoresis Enantiomer Separation Cyclodextrin Beta-cyclodextrin Derivative Chiral Drugs
刊名ANALYTICA CHIMICA ACTA
2000-09-21
421期:1页:27-34
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]ZONE-ELECTROPHORESIS ; CYCLOMALTOHEPTAOSE ; CHROMATOGRAPHY ; ETHER ; ACIDS
英文摘要The uncharged beta-cyclodextrin (beta-CD) derivative mono-3-O-phenylcarbamoyl-beta-CD was successfully used as chiral selector in capillary zone electrophoresis. Several chiral drugs such as propafenone and verapamil enantiomers belonging to different classes of compounds of pharmaceutical interest were resolved. The chiral resolution (Rs) was strongly influenced by the concentrations of the cyclodextrin derivative, the background electrolyte, and the pH of the background electrolyte. The influence of organic modifier was also studied. Under the conditions of 40 mmol/l berate buffer at pH 9.18 containing 2.5 mmol/l mono-3-phenylcarbamoyl-beta-CD, baseline separation (Rs=3.88 for verapamil, Rs=3.32 for propafenone) of the enantiomers can be achieved. (C) 2000 Elsevier Science B.V. All rights reserved.
语种英语
WOS记录号WOS:000089308800004
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138787
专题中国科学院大连化学物理研究所
作者单位1.Shandong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China
2.Acad Sinica, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
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GB/T 7714
Li, GB,Lin, XL,Zhu, CF,et al. New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs[J]. ANALYTICA CHIMICA ACTA,2000,421(1):27-34.
APA Li, GB,Lin, XL,Zhu, CF,Hao, AY,&Guan, YF.(2000).New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs.ANALYTICA CHIMICA ACTA,421(1),27-34.
MLA Li, GB,et al."New derivative of beta-cyclodextrin as chiral selectors for the capillary electrophoretic separation of chiral drugs".ANALYTICA CHIMICA ACTA 421.1(2000):27-34.
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