DICP OpenIR
Screening method for determining the presence of N-nitrosodiethanolamine in cosmetics by open-tubular capillary electrochromatography
Matyska, MT; Pesek, JJ; Yang, L
KeywordCosmetics Electrochromatography Nitrosodiethanolamine
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2000-07-28
Volume887Issue:1-2Pages:497-503
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; SKIN IN-VITRO ; PERCUTANEOUS PENETRATION ; NITROSAMINES ; VEHICLES ; PRODUCTS
AbstractThe presence of the carcinogenic N-nitrosodiethanolamine (NDELA; CAS No. 1116-54-7) in cosmetic samples was determined using an etched, C-18 modified capillary in the open-tubular capillary electrochromatography technique. A very simple extraction procedure leads to a sample matrix free from interferences. The calibration curve was created using UV detection at 214 nn. The detector response was linear in the range of 5-120 ppm total amount injected. Minimum detection limits (1 ppm NDELA injected on capillary) are suitable for screening a large number of cosmetic samples. Diethanolamine and triethanolamine precursors of nitrosamines are not detected at the wavelength used. Cosmetic samples were analyzed unspiked and after addition of 60 ppm of NDELA. In spiked samples recoveries varied from 94% (hand and body lotion) to 55% (lipstick sample). NDELA was found in unspiked samples of old (5-15 years old) cosmetics at concentrations of 14.0 ppm and 35.0 ppm. (C) 2000 Elsevier Science B.V. All rights reserved.
Language英语
WOS IDWOS:000088315800038
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/138802
Collection中国科学院大连化学物理研究所
Affiliation1.San Jose State Univ, Dept Chem, San Jose, CA 95192 USA
2.Acad Sinica, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Liaoning Provin, Peoples R China
Recommended Citation
GB/T 7714
Matyska, MT,Pesek, JJ,Yang, L. Screening method for determining the presence of N-nitrosodiethanolamine in cosmetics by open-tubular capillary electrochromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2000,887(1-2):497-503.
APA Matyska, MT,Pesek, JJ,&Yang, L.(2000).Screening method for determining the presence of N-nitrosodiethanolamine in cosmetics by open-tubular capillary electrochromatography.JOURNAL OF CHROMATOGRAPHY A,887(1-2),497-503.
MLA Matyska, MT,et al."Screening method for determining the presence of N-nitrosodiethanolamine in cosmetics by open-tubular capillary electrochromatography".JOURNAL OF CHROMATOGRAPHY A 887.1-2(2000):497-503.
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