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题名: Direct enantiomeric separation of non-steroidal anti-inflammatory drugs by high performance liquid chromatography
作者: Liu, XL;  Wang, JD;  Shang, ZH;  Yu, YN
关键词: high performance liquid chromatography ;  direct enantiomeric separation ;  non-steroidal antiinflammatory drugs ;  Kromasil chiral column
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2001-09-01
卷: 29, 期:9, 页:993-996
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Seven non-steroidal anti-inflammatory drugs (NSAIDs), i.e. carprofen, flurbiprofen, fenoprofen, ibuprofen, ketoprofen, naproxen and pirprofen, and mandelic acid were enantiomerically separated on a commercially available Kromasil CHI-TBB chiral stationary phase by high performance liquid chromatography in normal mode. It was found that mobile phase additives could tune the chiral separation factors and retention time of the solutes. Larger chiral separation factors (a) and longer retention time (t(R)) were generated by adding weaker polar additives, and smaller chiral separation factors and shorter retention time by adding stronger polar additives. Therefore, it is possible to modify the composition of the mobile phase for achieving different purposes.
语种: 英语
WOS记录号: WOS:000171295000001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138832
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China

Recommended Citation:
Liu, XL,Wang, JD,Shang, ZH,et al. Direct enantiomeric separation of non-steroidal anti-inflammatory drugs by high performance liquid chromatography[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2001,29(9):993-996.
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