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题名: Prediction of intestinal absorption of drugs with mimetic biomembrane chromatography
作者: Mao, XQ;  Zou, HF;  Luo, QZ;  Kong, L;  Li, X;  Sun, NC
关键词: mimetic biomembrane ;  chromatography ;  intestinal absorption ;  lecithin ;  drugs ;  silica
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2001-10-01
卷: 29, 期:10, 页:1135-1139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Silica coated lecithin was used as solid phase, the amount of lecithin coated and mechanical strength of the packing were all superior to gel, the traditional material used in the process of immobilization of liposome, and the stability of lecithin coated on silica was also good. The retention values of six drugs on mimetic biomembrane chromatography have been measured with three different pH buffers ( pH 5.4, pH 7.0 and pH 7.4) as mobile phase. The weighed retention values have been proposed to simulate the intestinal absorption of drugs. It was observed that the linear correlation coefficient (r = 0.9365) was higher than that with single buffer as mobile phase. Comparing the result above with that of correlation between retention of drugs on C-18 reversed phase chromatographic column and distributive coefficient of drugs in octanol-water system and intestinal absorption, it was observed that mimetic biomembrane chromatography had better precision than other two models when they were used to predict intestinal absorption of drugs.
关键词[WOS]: IMMOBILIZED-LIPOSOME ;  TRANSPORT
语种: 英语
WOS记录号: WOS:000171887300005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138879
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Mao, XQ,Zou, HF,Luo, QZ,et al. Prediction of intestinal absorption of drugs with mimetic biomembrane chromatography[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2001,29(10):1135-1139.
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