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题名: Enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate on cinchonidine-modified Pt/gamma-Al2O3 catalyst using a fixed-bed reactor
作者: Li, XH;  Li, C
关键词: cinchonidine-modified Pt/gamma-Al2O3 ;  enantioselective hydrogenation ;  fixed-bed reactor ;  heterogeneous catalyst ;  competitive adsorption
刊名: CATALYSIS LETTERS
发表日期: 2001
卷: 77, 期:4, 页:251-254
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: Enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate (EOPB) on a cinchonidine-modified Pt/gamma-Al2O3 catalyst was carried out using a fixed-bed reactor to obtain the chiral product, (R)-(+)-ethyl-2-hydroxy-4-phenylbutyrate ((R)-(+)-EHPB). About 95% conversion and 68% ee of the (R)-(+)-EHPB were obtained for the cinchonidine-modified Pt/gamma-Al2O3 catalyst in a continuous-flow reaction system with a fixed-bed reactor. It is observed that the ee of (R)-(+)-EHPB strongly depends on the different solvent and hydrogen pressure. The competitive adsorption between the solvent and reactant molecule plays an important role in determining the ee value of (R)-(+)-EHPB. This study also shows that a compact adsorption of chiral modifiers on the platinum surface is beneficial to the higher enantioselectivity.
关键词[WOS]: MODIFIED PLATINUM CATALYSTS ;  ALPHA-KETOESTERS ;  ETHYL PYRUVATE
语种: 英语
WOS记录号: WOS:000173459400014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138939
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Li, XH,Li, C. Enantioselective hydrogenation of ethyl-2-oxo-4-phenylbutyrate on cinchonidine-modified Pt/gamma-Al2O3 catalyst using a fixed-bed reactor[J]. CATALYSIS LETTERS,2001,77(4):251-254.
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