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Enantiomer separation of mandelates and their analogs on cyclodextrin derivative chiral stationary phases by capillary GC
Nie, MY; Zhou, LM; Wang, QH; Zhu, DQ
刊名ANALYTICAL SCIENCES
2001-10-01
17期:10页:1183-1187
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]GAS-CHROMATOGRAPHY ; RESOLUTION
英文摘要Enantiomer separation of mandelates and their analogs, which are important intermediates in asymmetric synthetic and pharmaceutical chemistry, was investigated by capillary gas chromatography using different cyclodextrin derivative chiral stationary phases (CD CSPs). The used cyclodextrin derivatives included permethylated beta -CD (PMBCD), permethylated gamma -CD, heptakis(2,6-di-O-butyl-3-O-butyryl)-beta -CD, heptakis(2,6-di-O-pentyl-3-O-acetyl)-beta -CD and heptakis(2,6-di-O-nonyl-3-O-trifluoroacetyl)-beta -CD (DNTBCD), respectively. Among all the CSPs used, PMBCD and DNTBCD exhibited the broadest and best enantioselectivity for all the racemates investigated. Some thermodynamic parameters were evaluated and an enthalpy-entropy compensation effect was observed in enantiomer separation processes of mandelates and their analogs. Based on thermodynamic data and molecular mechanics calculations, the chiral recognition mechanism of mandelate derivatives on CD CSPs is discussed.
语种英语
WOS记录号WOS:000171855500009
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/138957
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
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GB/T 7714
Nie, MY,Zhou, LM,Wang, QH,et al. Enantiomer separation of mandelates and their analogs on cyclodextrin derivative chiral stationary phases by capillary GC[J]. ANALYTICAL SCIENCES,2001,17(10):1183-1187.
APA Nie, MY,Zhou, LM,Wang, QH,&Zhu, DQ.(2001).Enantiomer separation of mandelates and their analogs on cyclodextrin derivative chiral stationary phases by capillary GC.ANALYTICAL SCIENCES,17(10),1183-1187.
MLA Nie, MY,et al."Enantiomer separation of mandelates and their analogs on cyclodextrin derivative chiral stationary phases by capillary GC".ANALYTICAL SCIENCES 17.10(2001):1183-1187.
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