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题名: Chiral separation of lobeline and benzhexol by capillary electrophoresis using the reaction mixture of beta-cyclodextrin, phosphorous-pentoxide and L-glutamic acid as chiral selector
作者: Lin, XL;  Li, GB;  Jiang, WQ;  Chu, YB;  Wu, P;  Yafeng, G
关键词: chiral separation ;  drug ;  lobeline ;  benzhexol ;  capillary electrophoresis
刊名: ANALYTICA CHIMICA ACTA
发表日期: 2001-03-08
卷: 431, 期:1, 页:41-48
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: The reaction mixture of beta -cyclodextrin, phosphorous-pentoxide and L-glutamic acid was successfully used as chiral selector in capillary zone electrophoresis. The reaction process and the main properties of the reaction mixture was introduced in detail. The enantiomeric separation of lobeline and benzhexol were investigated. The chiral resolution was strongly influenced by the concentration of the reaction mixture, pH and the organic modifier. The two compounds studied can be enantiomerically resolved with a high resolution for lobeline (Rs = 2.37) and benzhexol (Rs = 2.60) in less than 14 min with no capillary treatment. A possible separation mechanism and several factors influencing the chiral separation were discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
关键词[WOS]: ZONE ELECTROPHORESIS ;  ENANTIOMERS ;  CHROMATOGRAPHY ;  RESOLUTION ;  ADDITIVES
语种: 英语
WOS记录号: WOS:000167571700004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/138998
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shangdong Inst Light Ind, Dept Chem Engn, Jinan 250100, Peoples R China
2.Dalian Inst Chem Phys, Dalian 116012, Peoples R China

Recommended Citation:
Lin, XL,Li, GB,Jiang, WQ,et al. Chiral separation of lobeline and benzhexol by capillary electrophoresis using the reaction mixture of beta-cyclodextrin, phosphorous-pentoxide and L-glutamic acid as chiral selector[J]. ANALYTICA CHIMICA ACTA,2001,431(1):41-48.
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