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题名: Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin
作者: Ye, ML;  Zou, HF;  Lei, ZD;  Wu, RN;  Liu, Z;  Ni, JY
关键词: enantiomer separation ;  electrochromatography ;  strong anion-exchange stationary phase dynamically modified stationary phase ;  sulfated beta-cyclodextrin
刊名: ELECTROPHORESIS
发表日期: 2001-02-01
卷: 22, 期:3, 页:518-525
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A novel mode of capillary electrochromatography (CEG) based on a dynamically modified stationary phase was presented for chiral separation. The capillary column was packed with strong anion-exchange (SAX) stationary phase packing; the sulfated beta -cyclodextrin (S-CD), which was added to the mobile phase, was dynamically adsorbed to the packing surface. Separation of enantiomers was achieved by their different abilities to farm an inclusion complex with the adsorbed S-CD. The enantiomers of tryptophan, praziquantel, atropine, metoprolol, and verapamil were successfully separated in this system with a column efficiency of 36000-412000 plates/m. The resolution value obtained for atropine was as high as 11.23. The superiority of CEC with a dynamically modified stationary phase over that with a physically adsorbed stationary phase was demonstrated. The influence of ionic strength, S-CD concentration, and methanol content on separation was also studied.
关键词[WOS]: MODIFIED CATIONIC SURFACTANT ;  CHIRAL STATIONARY-PHASE ;  ION-EXCHANGE ;  ELECTROPHORESIS ;  SELECTIVITY ;  COLUMN
语种: 英语
WOS记录号: WOS:000167362400023
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139017
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Ye, ML,Zou, HF,Lei, ZD,et al. Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin[J]. ELECTROPHORESIS,2001,22(3):518-525.
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