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Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin
Ye, ML; Zou, HF; Lei, ZD; Wu, RN; Liu, Z; Ni, JY
关键词Enantiomer Separation Electrochromatography Strong Anion-exchange Stationary Phase Dynamically Modified Stationary Phase Sulfated Beta-cyclodextrin
刊名ELECTROPHORESIS
2001-02-01
22期:3页:518-525
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]MODIFIED CATIONIC SURFACTANT ; CHIRAL STATIONARY-PHASE ; ION-EXCHANGE ; ELECTROPHORESIS ; SELECTIVITY ; COLUMN
英文摘要A novel mode of capillary electrochromatography (CEG) based on a dynamically modified stationary phase was presented for chiral separation. The capillary column was packed with strong anion-exchange (SAX) stationary phase packing; the sulfated beta -cyclodextrin (S-CD), which was added to the mobile phase, was dynamically adsorbed to the packing surface. Separation of enantiomers was achieved by their different abilities to farm an inclusion complex with the adsorbed S-CD. The enantiomers of tryptophan, praziquantel, atropine, metoprolol, and verapamil were successfully separated in this system with a column efficiency of 36000-412000 plates/m. The resolution value obtained for atropine was as high as 11.23. The superiority of CEC with a dynamically modified stationary phase over that with a physically adsorbed stationary phase was demonstrated. The influence of ionic strength, S-CD concentration, and methanol content on separation was also studied.
语种英语
WOS记录号WOS:000167362400023
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139017
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
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GB/T 7714
Ye, ML,Zou, HF,Lei, ZD,et al. Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin[J]. ELECTROPHORESIS,2001,22(3):518-525.
APA Ye, ML,Zou, HF,Lei, ZD,Wu, RN,Liu, Z,&Ni, JY.(2001).Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin.ELECTROPHORESIS,22(3),518-525.
MLA Ye, ML,et al."Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin".ELECTROPHORESIS 22.3(2001):518-525.
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