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题名: Chiral separation by capillary electrochromatography with physically adsorbed stationary phase and dynamically modified stationary phase
作者: Ye, ML;  Zou, HF;  Lei, ZD;  Wu, RN;  Li, JY
关键词: capillary electrochromatography ;  dynamical modification ;  adsorbed stationary phase ;  enantiomer separation
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2001-03-01
卷: 29, 期:3, 页:299-302
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A novel mode of chiral separation in electrochromatogaphy (CEC) with dynamically modified stationary phase (DMS-CEC) was presented. The capillary column was packed with strong anionic exchange stationary phase, the sulfated beta -cyclodextrin (S-CD), which was added in the mobile phase, dynamically adsorbed to the packing surface and a new layer of chiral stationary phase was formed. The separation of enantiomer was based on their different interaction with the new stationary phase. The enantionmers of tryptophan, atropine and verapamil were successfully separated in this system with resolution of 2.06, 10.1 and 1.96, and the column efficiency for the enantiomers were varied from 85000 plates/m to 412000 plates/m. The relative standard deviation (RSD) of void time and the tryptophan enantiomers' migration time for 17 consecutive runs were 0.5%, 0.6% and 0.7%, respectively. Enantiomer separation by capillary electrochromatogaphy with absorbed bovine serum albumin (BSA) and sulfated cyclodextrin (S-CD) as chiral stationary phases were also studied. The resolution for tryptophan enantiomers in the two systems were 3.86 and 2.97, respectively. It was found that the superiority of DMS-CEC over the adsorbed S-CD column CEC was that better repeatability could be obtained in DRIS-CEC.
关键词[WOS]: MODIFIED CATIONIC SURFACTANT ;  BETA-CYCLODEXTRIN ;  ENANTIOMERS ;  SILICA ;  COLUMN
语种: 英语
WOS记录号: WOS:000167761200014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139040
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Ye, ML,Zou, HF,Lei, ZD,et al. Chiral separation by capillary electrochromatography with physically adsorbed stationary phase and dynamically modified stationary phase[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2001,29(3):299-302.
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