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Separation of enantiomers on bonded cellulose trisphenylcarbamate stationary phase by high-performance liquid chromatography
Chen, XM; Mao, XQ; Zhang, ZZ; Luo, QZ; Zou, HF
关键词Cellulose Derivative Chiral Stationary Phase Hplc Enantiomeric Separation
刊名ACTA CHIMICA SINICA
2002
60期:1页:93-97
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
英文摘要Cellulose trisphenylcarbamate was regioselectively bonded to 3-aminopropyl silica gel at 6-position of the primary hydroxyl group on the glucose unit of cellulose with 4,4'-diphenylmethane diisocyanate as a spacer. Nine racemates were resolved on the prepared stationary phase under normal-HPLC mobile phases. It was observed that enantioseparations, on the bonded-phase showed higher efficiency by using tetrahydrofuran as a component of the mobile phase, and the structure of the derivative agent reacted with the amino acids played a role for the enantioseparation. Chiral separation on the bonded phase under reversed-HPLC mobile phase was also performed successfully. It has been shown that the retention factors of the racemates decreased appreciably with the increment of the concentration of acetonitrile in the mobile phase, while no significant change was observed for the enantioselectivity. Separation of enantiomer for the acidic racemate could be improved with a lower pH value of the mobile phase since the dissociation of acidic compound was impressed, but it did not affect significantly the resolution of neutral compounds.
语种英语
WOS记录号WOS:000173368700018
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139205
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
推荐引用方式
GB/T 7714
Chen, XM,Mao, XQ,Zhang, ZZ,et al. Separation of enantiomers on bonded cellulose trisphenylcarbamate stationary phase by high-performance liquid chromatography[J]. ACTA CHIMICA SINICA,2002,60(1):93-97.
APA Chen, XM,Mao, XQ,Zhang, ZZ,Luo, QZ,&Zou, HF.(2002).Separation of enantiomers on bonded cellulose trisphenylcarbamate stationary phase by high-performance liquid chromatography.ACTA CHIMICA SINICA,60(1),93-97.
MLA Chen, XM,et al."Separation of enantiomers on bonded cellulose trisphenylcarbamate stationary phase by high-performance liquid chromatography".ACTA CHIMICA SINICA 60.1(2002):93-97.
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