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题名: The multicriteria-decision-making simultaneous optimization based on genetic algorithm in chiral capillary electrophoresis separation
作者: Xiong, JH;  Zhang, PD;  Shi, XZ;  Zhang, YK;  Xu, GW
关键词: capillary electrophoresis ;  genetic algorithm ;  desirability function ;  enantiomer separation ;  multicritiria optimization
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2004-05-01
卷: 25, 期:5, 页:896-899
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: A methodology based on the combination of desirability function approach and genetic algorithm was applied to the multicriteria-decision-making simultaneous optimization of epinephrine enantiomers by capillary electrophoresis. Uniform design, an experimental design method, was employed to examine how the factors such as electrolyte concentration, pH, concentration of chiral selector and voltage affected resolution, analysis time and peak height. In order to achieve the simultaneous optimization of the three goals for efficient, fast and highly sensitive separation, the Derringer desirability functions were tested. The real-value encoded genetic algorithm was used to achieve the search for maximizing desirability and several optimal separation conditions were obtained. Under the optimized conditions, the values of total desirability functions were increased by 10.4% in comparison to those under the optimal condition defined by the uniform design experiment.
关键词[WOS]: ENANTIOMERIC SEPARATION ;  CHROMATOGRAPHY
语种: 英语
WOS记录号: WOS:000221514700028
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139291
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Xiong, JH,Zhang, PD,Shi, XZ,et al. The multicriteria-decision-making simultaneous optimization based on genetic algorithm in chiral capillary electrophoresis separation[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2004,25(5):896-899.
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