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题名: Investigation of norvancomycin chiral stationary phase for the enantioseparation of derived amino acids on reversed phase conditions
作者: Ding, GS;  Cong, RZ;  Wang, J
关键词: norwancomycin ;  chiral stationary phase ;  high performance liquid chromatography ;  chiral separation ;  dansyl-amino acids
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2004-05-01
卷: 32, 期:5, 页:606-610
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Using the newly synthesized norvancomycin chiral stationary phase (NVC-CSP), the enantiomers of dansyl-alpha-amino-n-butyric acid (Dns-But), dansyl-methionine (Dns-Met) dansyl-threonine (Dns-Thr) and dansyl-glutamic acid (Dns-Glu) were directly separated on reversed phase conditions. The influences of some chromatographic parameters, such as pH of buffer, the content of organic modifier, temperature and flow rate, were evaluated, and furthermore, the possible mechanism of chiral discrimination was discussed. It was found experimentally that hydrophobic, as well as ionic interactions were important for solute's retention and enantioselectivity in this chromatographic system, and the chiral recognition mechanism was similar to that of protein-based CSPs.
关键词[WOS]: MACROCYCLIC ANTIBIOTICS ;  LIQUID-CHROMATOGRAPHY ;  TEICOPLANIN ;  SELECTORS
语种: 英语
WOS记录号: WOS:000221785200012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139339
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China

Recommended Citation:
Ding, GS,Cong, RZ,Wang, J. Investigation of norvancomycin chiral stationary phase for the enantioseparation of derived amino acids on reversed phase conditions[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2004,32(5):606-610.
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