DICP OpenIR
Investigation of norvancomycin chiral stationary phase for the enantioseparation of derived amino acids on reversed phase conditions
Ding, GS; Cong, RZ; Wang, J
KeywordNorwancomycin Chiral Stationary Phase High Performance Liquid Chromatography Chiral Separation Dansyl-amino Acids
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
2004-05-01
Volume32Issue:5Pages:606-610
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordMACROCYCLIC ANTIBIOTICS ; LIQUID-CHROMATOGRAPHY ; TEICOPLANIN ; SELECTORS
AbstractUsing the newly synthesized norvancomycin chiral stationary phase (NVC-CSP), the enantiomers of dansyl-alpha-amino-n-butyric acid (Dns-But), dansyl-methionine (Dns-Met) dansyl-threonine (Dns-Thr) and dansyl-glutamic acid (Dns-Glu) were directly separated on reversed phase conditions. The influences of some chromatographic parameters, such as pH of buffer, the content of organic modifier, temperature and flow rate, were evaluated, and furthermore, the possible mechanism of chiral discrimination was discussed. It was found experimentally that hydrophobic, as well as ionic interactions were important for solute's retention and enantioselectivity in this chromatographic system, and the chiral recognition mechanism was similar to that of protein-based CSPs.
Language英语
WOS IDWOS:000221785200012
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/139339
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
Recommended Citation
GB/T 7714
Ding, GS,Cong, RZ,Wang, J. Investigation of norvancomycin chiral stationary phase for the enantioseparation of derived amino acids on reversed phase conditions[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2004,32(5):606-610.
APA Ding, GS,Cong, RZ,&Wang, J.(2004).Investigation of norvancomycin chiral stationary phase for the enantioseparation of derived amino acids on reversed phase conditions.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,32(5),606-610.
MLA Ding, GS,et al."Investigation of norvancomycin chiral stationary phase for the enantioseparation of derived amino acids on reversed phase conditions".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 32.5(2004):606-610.
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