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题名: Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases
作者: Yang, J;  Xu, GW;  Zheng, YF;  Kong, HW;  Pang, T;  Lv, S;  Yang, Q
关键词: metabonomics ;  HPLC ;  nucleosides ;  methodological studies ;  molecular diagnosis and prognosis
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2004-12-25
DOI: 10.1016/j.jchromb.2004.09.032
卷: 813, 期:1-2, 页:59-65
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Metabonomics, the study of metabolites and their roles in various disease states, is a novel methodology arising from the post-genomics era. This methodology has been applied in many fields. Current metabonomics practice has relied on mass spectrometry (MS), gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) to analyze metabolites. In this study, a novel approach of using high-performance liquid chromatography (HPLC) in conjunction with developed software was employed. Using the principal components analysis method (PCA), all (113) peaks of urinary metabolites with a cis-diol structure from patients with hepatitis and hepatocirrhosis were compared to those from liver cancer patients. The results showed that the metabonomics-PCA method might be useful to differentiate between patients with hepatocirrhosis and hepatitis from patients with liver cancer while lowering false-positive rate. These findings also suggest that a subset of the urinary nucleosides identified with metabonomics correlate better with cancer diagnosis than the traditional single tumor marker alpha-fetoprotein (AFP). (C) 2004 Elsevier B.V. All rights reserved.
关键词[WOS]: NEURAL-NETWORK CLASSIFICATION ;  MODIFIED NUCLEOSIDES ;  FUNCTIONAL GENOMICS ;  URINARY NUCLEOSIDES ;  TRANSFER-RNA ;  CHROMATOGRAPHY ;  PSEUDOURIDINE ;  METABOLOMICS ;  H-1-NMR ;  TOF/MS
语种: 英语
WOS记录号: WOS:000225413200006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139458
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Dalian Med Univ, Dept Pathol, Dalian 116023, Peoples R China

Recommended Citation:
Yang, J,Xu, GW,Zheng, YF,et al. Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2004,813(1-2):59-65.
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