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题名: Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat
作者: Pi, RB;  Yin, W;  Zheng, SQ;  Qiu, PX;  Zhou, J;  Guo, W;  Su, T;  Yan, GM
关键词: neurons ;  adenoviral mediated transfer ;  TIMP-3 ;  neuroprotection ;  glutamate
刊名: MOLECULAR BRAIN RESEARCH
发表日期: 2004-08-23
DOI: 10.1016/j.molbrainres.2004.02.026
卷: 127, 期:1-2, 页:136-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
英文摘要: Metalloproteinases and tissue inhibitor of metalloproteinases (TIMPs) are associated with tissue reorganization after injury. The up-regulation of TIMP-3 has recently been found in ischemic brain although its functional implications are unclear. In this study we show that overexpression of TIMP-3 by adenovirus-mediated gene transfer partially protects neurons against excitotoxic death induced by glutamate in culture. The partial neuroprotection afforded by TIMP-3 has implications for our understanding of the physiological role of TIMP-3 in the normal and damaged central nervous system. (C) 2004 Elsevier B.V. All rights reserved.
关键词[WOS]: CHICKEN-EMBRYO FIBROBLASTS ;  TISSUE INHIBITOR ;  EXTRACELLULAR-MATRIX ;  METALLOPROTEINASE-3 ;  PROTEIN ;  TRANSFORMATION ;  APOPTOSIS ;  SURVIVAL ;  GROWTH
语种: 英语
WOS记录号: WOS:000223567300015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139476
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Dept Pharmacol, Zhongshan Med Coll, Guangzhou 510080, Peoples R China
2.Acad China, Inst Microbiol, Dept Biotechnol, Beijing 100800, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Med Coll, Dept Forens Pathol, Guangzhou 510080, Peoples R China

Recommended Citation:
Pi, RB,Yin, W,Zheng, SQ,et al. Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat[J]. MOLECULAR BRAIN RESEARCH,2004,127(1-2):136-139.
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