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Modeling, by frontal analysis, of the adsorption of bovine serum albumin on cibacron blue-modified cellulose membranes
Hao, WQ; Wang, JD; Li, JH
关键词Membrane-affinity Chromatography Frontal Analysis Cibacron Blue F3ga Bovine Serum Albumin
刊名CHROMATOGRAPHIA
2004-10-01
DOI10.1365/s10337-004-0398-2
60期:7-8页:449-454
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]AFFINITY-MEMBRANE ; SORPTION KINETICS ; CHROMATOGRAPHY ; BIOSEPARATIONS ; PROTEINS ; BREAKTHROUGH ; PURIFICATION ; DESIGN
英文摘要The adsorption of bovine serum albumin (BSA) on cibacron blue F3GA cellulose affinity membranes has been studied by frontal analysis. The ideal stirred tank (IST) model, the modified stirred tank (MST) model, and the equilibrium-dispersive (E-D) model were used to describe experimental breakthrough curves. The E-D model was found to best describe the initial region of the breakthrough curve whereas the MST model was best for the late region, implying a difference between the initial and late stages of adsorption. According to the E-D model, the effect of axial dispersion was not negligible, possibly because of experimental factors such as inhomogeneous distribution of the feed solution and the thinness of affinity membranes. The variable a of the MST model can be taken as the adjusted number of theoretical plates of the affinity membranes. The maximum value of a was found experimentally by varying the flow rate; increasing the feed concentration led to a smaller value of alpha.
语种英语
WOS记录号WOS:000224907300013
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139496
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
推荐引用方式
GB/T 7714
Hao, WQ,Wang, JD,Li, JH. Modeling, by frontal analysis, of the adsorption of bovine serum albumin on cibacron blue-modified cellulose membranes[J]. CHROMATOGRAPHIA,2004,60(7-8):449-454.
APA Hao, WQ,Wang, JD,&Li, JH.(2004).Modeling, by frontal analysis, of the adsorption of bovine serum albumin on cibacron blue-modified cellulose membranes.CHROMATOGRAPHIA,60(7-8),449-454.
MLA Hao, WQ,et al."Modeling, by frontal analysis, of the adsorption of bovine serum albumin on cibacron blue-modified cellulose membranes".CHROMATOGRAPHIA 60.7-8(2004):449-454.
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