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题名: Interaction between domoic acid and double-stranded oligodeoxy-nucleotide studied by using microchip-based non-gel sieving electrophoresis
作者: Zhou, XM;  Li, DZ;  Shen, Z;  Liu, W;  Li, GR;  Lin, BC
关键词: microchip non-sieving electrophoresis ;  interaction ;  domoic acid ;  18-mer dsDNA
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2005-07-10
卷: 26, 期:7, 页:1252-1254
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The interaction between domoic acid(DA) and 18-mer double-stranded DNA(dsDNA) was investigated by using microchip-based non-gel sieving electrophoresis. For the 18-mer dsDNA with a sequence of 3-GCATTGGTTGACGTTGCA-5', the amount of free dsDNA decreases with the increase of the added DA and also with the increase of reactive time. Meanwhile, the newly-produced two peaks were observed. The experimental results show that there is a strong interaction between DA and the 18-mer dsDNA. DA makes the degradation of the 18-mer dsDNA. The non-gel sieving electrophoresis on microchip is a rapid, convenient, highly sensitive method for studying the interaction between DNA and small molecules.
语种: 英语
WOS记录号: WOS:000230753000016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139625
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Guangzhou First Municipal Peoples Hosp, Guangzhou Med Coll, Dept Clin Lab, Guangzhou 510500, Guangdong, Peoples R China
3.Dalian Customs Lab, Dalian 116001, Peoples R China
4.Dalian Med Univ, Affiliated Hosp 2, Dalian 116023, Peoples R China

Recommended Citation:
Zhou, XM,Li, DZ,Shen, Z,et al. Interaction between domoic acid and double-stranded oligodeoxy-nucleotide studied by using microchip-based non-gel sieving electrophoresis[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2005,26(7):1252-1254.
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