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The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation
Ren, DW; Yi, HF; Wang, W; Ma, XJ
关键词Enzymatic Degradation Chitosan Matrices N-acetylation Biomedical Materials
刊名CARBOHYDRATE RESEARCH
2005-10-31
DOI10.1016/j.carres.2005.07.022
340期:15页:2403-2410
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]MECHANICAL-PROPERTIES ; ALGINATE-CHITOSAN ; IN-VITRO ; LYSOZYME ; CARTILAGE ; SCAFFOLD ; FILMS ; MICROCAPSULES ; MICROSPHERES ; DERIVATIVES
英文摘要In the design of chitosan-based drug delivery systems and implantable scaffolds, the biodegradation rate of the chitosan matrix represents a promising strategy for drug delivery and the function of carriers. In this study, we have investigated the degradation of chitosan with different degrees of N-acetylation, with respect to weight loss, water absorption.. swelling behavior, molecular weight loss of bulk materials, and reducing sugar content in the media. Chitosan matrices were prepared by compression molding. The results revealed that the initial degradation rate, equilibrium water absorption, and swelling degree increased with decreasing degree of deacetylation (DD) and a dramatic rise began as DD of the chitosan matrix decreased to 62.4%. Chitosan matrices with DD of 52.6%, 56.1%, and 62.4% had the weight half-life of 9.8, 27.3, and more than 56 days, respectively, and the weight half-life of average molecular weight 8.4, 8.8, and 20.0 days, respectively. For chitosan matrices with DD of 71.7%, 81.7%, and 93.5%, both types of half-life exceeded 84 days because of the much slower degradation rate. The dimension of chitosan matrices during degradation was determined by the process of swelling and degradation. These findings may help to design chitosan-based biomedical materials with predetermined degradation timed from several days to months and proper swelling behaviors. (C) 2005 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000232645600007
引用统计
被引频次:186[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139640
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Ren, DW,Yi, HF,Wang, W,et al. The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation[J]. CARBOHYDRATE RESEARCH,2005,340(15):2403-2410.
APA Ren, DW,Yi, HF,Wang, W,&Ma, XJ.(2005).The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation.CARBOHYDRATE RESEARCH,340(15),2403-2410.
MLA Ren, DW,et al."The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation".CARBOHYDRATE RESEARCH 340.15(2005):2403-2410.
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