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The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation
Ren, DW; Yi, HF; Wang, W; Ma, XJ
KeywordEnzymatic Degradation Chitosan Matrices N-acetylation Biomedical Materials
Source PublicationCARBOHYDRATE RESEARCH
2005-10-31
DOI10.1016/j.carres.2005.07.022
Volume340Issue:15Pages:2403-2410
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordMECHANICAL-PROPERTIES ; ALGINATE-CHITOSAN ; IN-VITRO ; LYSOZYME ; CARTILAGE ; SCAFFOLD ; FILMS ; MICROCAPSULES ; MICROSPHERES ; DERIVATIVES
AbstractIn the design of chitosan-based drug delivery systems and implantable scaffolds, the biodegradation rate of the chitosan matrix represents a promising strategy for drug delivery and the function of carriers. In this study, we have investigated the degradation of chitosan with different degrees of N-acetylation, with respect to weight loss, water absorption.. swelling behavior, molecular weight loss of bulk materials, and reducing sugar content in the media. Chitosan matrices were prepared by compression molding. The results revealed that the initial degradation rate, equilibrium water absorption, and swelling degree increased with decreasing degree of deacetylation (DD) and a dramatic rise began as DD of the chitosan matrix decreased to 62.4%. Chitosan matrices with DD of 52.6%, 56.1%, and 62.4% had the weight half-life of 9.8, 27.3, and more than 56 days, respectively, and the weight half-life of average molecular weight 8.4, 8.8, and 20.0 days, respectively. For chitosan matrices with DD of 71.7%, 81.7%, and 93.5%, both types of half-life exceeded 84 days because of the much slower degradation rate. The dimension of chitosan matrices during degradation was determined by the process of swelling and degradation. These findings may help to design chitosan-based biomedical materials with predetermined degradation timed from several days to months and proper swelling behaviors. (C) 2005 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000232645600007
Citation statistics
Cited Times:196[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/139640
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Ren, DW,Yi, HF,Wang, W,et al. The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation[J]. CARBOHYDRATE RESEARCH,2005,340(15):2403-2410.
APA Ren, DW,Yi, HF,Wang, W,&Ma, XJ.(2005).The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation.CARBOHYDRATE RESEARCH,340(15),2403-2410.
MLA Ren, DW,et al."The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation".CARBOHYDRATE RESEARCH 340.15(2005):2403-2410.
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