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题名: The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation
作者: Ren, DW;  Yi, HF;  Wang, W;  Ma, XJ
关键词: enzymatic degradation ;  chitosan matrices ;  N-acetylation ;  biomedical materials
刊名: CARBOHYDRATE RESEARCH
发表日期: 2005-10-31
DOI: 10.1016/j.carres.2005.07.022
卷: 340, 期:15, 页:2403-2410
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Chemistry, Applied ;  Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: In the design of chitosan-based drug delivery systems and implantable scaffolds, the biodegradation rate of the chitosan matrix represents a promising strategy for drug delivery and the function of carriers. In this study, we have investigated the degradation of chitosan with different degrees of N-acetylation, with respect to weight loss, water absorption.. swelling behavior, molecular weight loss of bulk materials, and reducing sugar content in the media. Chitosan matrices were prepared by compression molding. The results revealed that the initial degradation rate, equilibrium water absorption, and swelling degree increased with decreasing degree of deacetylation (DD) and a dramatic rise began as DD of the chitosan matrix decreased to 62.4%. Chitosan matrices with DD of 52.6%, 56.1%, and 62.4% had the weight half-life of 9.8, 27.3, and more than 56 days, respectively, and the weight half-life of average molecular weight 8.4, 8.8, and 20.0 days, respectively. For chitosan matrices with DD of 71.7%, 81.7%, and 93.5%, both types of half-life exceeded 84 days because of the much slower degradation rate. The dimension of chitosan matrices during degradation was determined by the process of swelling and degradation. These findings may help to design chitosan-based biomedical materials with predetermined degradation timed from several days to months and proper swelling behaviors. (C) 2005 Elsevier Ltd. All rights reserved.
关键词[WOS]: MECHANICAL-PROPERTIES ;  ALGINATE-CHITOSAN ;  IN-VITRO ;  LYSOZYME ;  CARTILAGE ;  SCAFFOLD ;  FILMS ;  MICROCAPSULES ;  MICROSPHERES ;  DERIVATIVES
语种: 英语
WOS记录号: WOS:000232645600007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139640
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Ren, DW,Yi, HF,Wang, W,et al. The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation[J]. CARBOHYDRATE RESEARCH,2005,340(15):2403-2410.
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