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题名: Multicriteria-decision-making simultaneous optimization independent of statistical models in chiral capillary electrophoresis separation
作者: Xiong, JH;  Weng, QF;  Yuan, KL;  Zhang, YK;  Xu, GW
关键词: capillary electrophoresis ;  optimization ;  genetic algorithm ;  uniform design ;  desirability function
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2005-06-01
卷: 33, 期:6, 页:755-758
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Considering the complexity of chiral capillary electrophoresis separation mechanism, a multicriteria-decision-making optimization approach based on binary-coded genetic algorithm, which was independent of the statistic model used, was developed. According to the experiment parameters and their importances, the initial experiments were arranged using a uniform design. In order to achieve the simultaneous optimization of the two major electrophoretic performance goals for efficient and fast separations, the Derringer desirability functions were chosen as the optimization criteriaon. The selected parameters were encoded into binary bit strings, and then genetic algorithm calculations were performed to generate a new set of experimental conditions by the values of total desirability functions. This cycle process was repeated until a best separation criterion was reached. The method proposed was successfully applied to the enantioseparation of warfarin by chiral capillary electrophoresis.
关键词[WOS]: BETA-CYCLODEXTRIN ;  ZONE-ELECTROPHORESIS ;  ACIDS
语种: 英语
WOS记录号: WOS:000230362500003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139663
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Xiong, JH,Weng, QF,Yuan, KL,et al. Multicriteria-decision-making simultaneous optimization independent of statistical models in chiral capillary electrophoresis separation[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2005,33(6):755-758.
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