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题名: Microfabrication and performance of poly(methyl methacrylate) microfluidic chip with multi-channels
作者: Zhou, XM;  Dai, ZP;  Luo, Y;  Liu, DY;  Wang, H;  Mao, XL;  Lin, BC
关键词: microfluldic plastic chip ;  capillary electrophoresis chip ;  microfabrication
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2005
卷: 26, 期:1, 页:52-54
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: The microchip capillary electrophoresis devices were fabricated by using poly (methyl methacrylate) (PMMA) plastic material via an injection-molding process. The molded devices were enclosed by utilizing a mixed organic solvent to another PMMA film. The channel structure was very well defined and the molded channel surfaces were very smooth. The transmissivity was in the range from 91% to 93% (at the wavelength of 400-1000 nm). In comparison to glass microchannels, the electroosmotic flow(EOF) in native PMMA channels was low. DNA marker separation was demonstrated in these PMMA devices with a high-resolution separation of double-stranded DNA fragments, chip-to-chip and the run-to-run reproducibility was good, and the relative standard deviation (%) values were below 2.2% for run-to-run data and 2.3% for the chip-to-chip comparisons. The PCR amplification products and proteins were analyzed on the PMMA chips. Such devices lead to the production of,low-cost, disposable chips suitable for a variety of separation applications, including DNA sizing, DNA sequencing, protein and medical analysis. The detection limits of Rhodamine 6G dye for the unmodified PMMA chip and the modified PMMA chips were 1.0x10(-10) and 6.67x10(-13) moI/L, respectively.
关键词[WOS]: FABRICATION ;  DEVICES
语种: 英语
WOS记录号: WOS:000226503000015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139671
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Zhou, XM,Dai, ZP,Luo, Y,et al. Microfabrication and performance of poly(methyl methacrylate) microfluidic chip with multi-channels[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2005,26(1):52-54.
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