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Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis
Wang, C; Kong, HW; Guan, YF; Yang, J; Gu, JR; Yang, SL; Xu, GW
刊名ANALYTICAL CHEMISTRY
2005-07-01
DOI10.1021/ac0481001
77期:13页:4108-4116
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]ELECTROSPRAY-IONIZATION ; PATTERN-RECOGNITION ; GAS-CHROMATOGRAPHY ; RAT URINE ; IDENTIFICATION ; SEPARATION ; METABONOMICS ; GLYCEROPHOSPHOLIPIDS ; DISCRIMINATION ; SPECTROSCOPY
英文摘要Liquid chromatography/mass spectrometry (LC/MS) followed by multivariate statistical analysis has been successfully applied to the plasma phospholipids metabolic profiling in type 2 diabetes mellitus (DM-2). Principal components analysis and partial least-squares discriminant analysis (PLS-DA) models were tested and compared in class separation between the DM2 and control. The application of an orthogonal signal correction filtered model highly improved the class distinction and predictive power of PLS-DA models. Additionally, unit variance scaling was also tested. With this methodology, it was possible not only to differentiate the DM2 from the control but also to discover and identify the potential biomarkers with LC/MS/MS. The proposed method shows that LC/MS combining with multivariate statistical analysis is a complement or an alternative to NMR for metabonomics applications.
语种英语
WOS记录号WOS:000230270800047
引用统计
被引频次:188[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139677
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatogr R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Affilated Hosp 2, Dalian 116023, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Canc Inst, Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai, Peoples R China
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GB/T 7714
Wang, C,Kong, HW,Guan, YF,et al. Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis[J]. ANALYTICAL CHEMISTRY,2005,77(13):4108-4116.
APA Wang, C.,Kong, HW.,Guan, YF.,Yang, J.,Gu, JR.,...&Xu, GW.(2005).Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis.ANALYTICAL CHEMISTRY,77(13),4108-4116.
MLA Wang, C,et al."Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis".ANALYTICAL CHEMISTRY 77.13(2005):4108-4116.
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