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题名: Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis
作者: Wang, C;  Kong, HW;  Guan, YF;  Yang, J;  Gu, JR;  Yang, SL;  Xu, GW
刊名: ANALYTICAL CHEMISTRY
发表日期: 2005-07-01
DOI: 10.1021/ac0481001
卷: 77, 期:13, 页:4108-4116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Liquid chromatography/mass spectrometry (LC/MS) followed by multivariate statistical analysis has been successfully applied to the plasma phospholipids metabolic profiling in type 2 diabetes mellitus (DM-2). Principal components analysis and partial least-squares discriminant analysis (PLS-DA) models were tested and compared in class separation between the DM2 and control. The application of an orthogonal signal correction filtered model highly improved the class distinction and predictive power of PLS-DA models. Additionally, unit variance scaling was also tested. With this methodology, it was possible not only to differentiate the DM2 from the control but also to discover and identify the potential biomarkers with LC/MS/MS. The proposed method shows that LC/MS combining with multivariate statistical analysis is a complement or an alternative to NMR for metabonomics applications.
关键词[WOS]: ELECTROSPRAY-IONIZATION ;  PATTERN-RECOGNITION ;  GAS-CHROMATOGRAPHY ;  RAT URINE ;  IDENTIFICATION ;  SEPARATION ;  METABONOMICS ;  GLYCEROPHOSPHOLIPIDS ;  DISCRIMINATION ;  SPECTROSCOPY
语种: 英语
WOS记录号: WOS:000230270800047
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139677
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatogr R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Affilated Hosp 2, Dalian 116023, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Canc Inst, Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai, Peoples R China

Recommended Citation:
Wang, C,Kong, HW,Guan, YF,et al. Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis[J]. ANALYTICAL CHEMISTRY,2005,77(13):4108-4116.
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