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题名: Chiral separations on multichannel microfluidic chips
作者: Gao, Y;  Shen, Z;  Wang, H;  Dai, ZP;  Lin, BC
关键词: chiral selector screening ;  LIF ;  microfluidic ;  multichannel ;  neutral CD
刊名: ELECTROPHORESIS
发表日期: 2005-12-01
DOI: 10.1002/elps.200500283
卷: 26, 期:24, 页:4774-4779
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Chiral separations of FITC-labeled basic drugs on multichannel microfluidic chips with LIF detector were investigated. A preliminary screening procedure for seven neutral CDs was performed under optimized conditions for chiral separations of three FITC-labeled drugs (baclofen, norfenefrine, and tocainide) on a mono-channel microfluidic chip. According to the results of screening, FITC-baclofen and FITC-norfenefrine as well as two chiral selectors including gamma-CD and dimethyl-beta-CD (DM-beta-CD) were selected as models to perform chiral separations on a two-channel chip. FITC-baclofen enantiomers were separated completely by gamma-CD in one channel, while resolution of FITC-norfenefrine enantiomers was achieved by DM-beta-CD in the other channel in the same run. Furthermore, the feasibility of using one chiral selector to separate multiple chiral samples was studied on a four-channel chip. These results show that multichannel chip has a potential for chiral high-throughput screening.
关键词[WOS]: MODIFIED CAPILLARY-ELECTROPHORESIS ;  PERFORMANCE LIQUID-CHROMATOGRAPHY ;  MICROCHIP ELECTROPHORESIS ;  ENANTIOMERIC RESOLUTION ;  ZONE-ELECTROPHORESIS ;  UV DETECTION ;  CYCLODEXTRINS ;  DERIVATIVES ;  SYSTEMS ;  ENANTIOSEPARATION
语种: 英语
WOS记录号: WOS:000234466300023
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139687
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Gao, Y,Shen, Z,Wang, H,et al. Chiral separations on multichannel microfluidic chips[J]. ELECTROPHORESIS,2005,26(24):4774-4779.
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