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题名: A dammarane glycoside derived from ginsenoside Rb-3
作者: He, KJ;  Liu, Y;  Yang, Y;  Li, P;  Yang, L
关键词: ginsenoside Rb-3 ;  compound Mx ;  structure ;  NMR data
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2005-02-01
卷: 53, 期:2, 页:177-179
收录类别: SCI ;  IC
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: A dammarane glycoside, designated compound Mx (C-Mx), was isolated from the hydrolysate of 20(S)-protopanaxadiol type ginsenosides containing G-Rb, from Panax notoginseng leaves with crude snailase. Its chemical structure was elucidated to be 20-O-beta-o-xylopyranosyl(1 --> 6)-beta-D-glucopyranosyl-20(S)-protopanaxadiol on the basis of spectral analysis. Its cytotoxicity against breast cancer cell line MCF-7 and effects on the sensitivity to doxocubicin of doxocubicin-resistant MCF-7 cells were also investigated. The new compound showed moderate cytotoxicity and partial reversal of doxocubicin resistance.
关键词[WOS]: INTESTINAL BACTERIA ;  IN-VITRO ;  METABOLISM ;  ABSORPTION ;  EXCRETION ;  SAPONINS ;  RAT ;  CYTOTOXICITY ;  RESISTANT
语种: 英语
WOS记录号: WOS:000226999100006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139727
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China

Recommended Citation:
He, KJ,Liu, Y,Yang, Y,et al. A dammarane glycoside derived from ginsenoside Rb-3[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2005,53(2):177-179.
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