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A dammarane glycoside derived from ginsenoside Rb-3
He, KJ; Liu, Y; Yang, Y; Li, P; Yang, L
KeywordGinsenoside Rb-3 Compound Mx Structure Nmr Data
Source PublicationCHEMICAL & PHARMACEUTICAL BULLETIN
2005-02-01
Volume53Issue:2Pages:177-179
Indexed BySCI ; IC
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectChemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS KeywordINTESTINAL BACTERIA ; IN-VITRO ; METABOLISM ; ABSORPTION ; EXCRETION ; SAPONINS ; RAT ; CYTOTOXICITY ; RESISTANT
AbstractA dammarane glycoside, designated compound Mx (C-Mx), was isolated from the hydrolysate of 20(S)-protopanaxadiol type ginsenosides containing G-Rb, from Panax notoginseng leaves with crude snailase. Its chemical structure was elucidated to be 20-O-beta-o-xylopyranosyl(1 --> 6)-beta-D-glucopyranosyl-20(S)-protopanaxadiol on the basis of spectral analysis. Its cytotoxicity against breast cancer cell line MCF-7 and effects on the sensitivity to doxocubicin of doxocubicin-resistant MCF-7 cells were also investigated. The new compound showed moderate cytotoxicity and partial reversal of doxocubicin resistance.
Language英语
WOS IDWOS:000226999100006
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/139727
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China
Recommended Citation
GB/T 7714
He, KJ,Liu, Y,Yang, Y,et al. A dammarane glycoside derived from ginsenoside Rb-3[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2005,53(2):177-179.
APA He, KJ,Liu, Y,Yang, Y,Li, P,&Yang, L.(2005).A dammarane glycoside derived from ginsenoside Rb-3.CHEMICAL & PHARMACEUTICAL BULLETIN,53(2),177-179.
MLA He, KJ,et al."A dammarane glycoside derived from ginsenoside Rb-3".CHEMICAL & PHARMACEUTICAL BULLETIN 53.2(2005):177-179.
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