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A dammarane glycoside derived from ginsenoside Rb-3
He, KJ; Liu, Y; Yang, Y; Li, P; Yang, L
关键词Ginsenoside Rb-3 Compound Mx Structure Nmr Data
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
2005-02-01
53期:2页:177-179
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]INTESTINAL BACTERIA ; IN-VITRO ; METABOLISM ; ABSORPTION ; EXCRETION ; SAPONINS ; RAT ; CYTOTOXICITY ; RESISTANT
英文摘要A dammarane glycoside, designated compound Mx (C-Mx), was isolated from the hydrolysate of 20(S)-protopanaxadiol type ginsenosides containing G-Rb, from Panax notoginseng leaves with crude snailase. Its chemical structure was elucidated to be 20-O-beta-o-xylopyranosyl(1 --> 6)-beta-D-glucopyranosyl-20(S)-protopanaxadiol on the basis of spectral analysis. Its cytotoxicity against breast cancer cell line MCF-7 and effects on the sensitivity to doxocubicin of doxocubicin-resistant MCF-7 cells were also investigated. The new compound showed moderate cytotoxicity and partial reversal of doxocubicin resistance.
语种英语
WOS记录号WOS:000226999100006
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被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139727
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China
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GB/T 7714
He, KJ,Liu, Y,Yang, Y,et al. A dammarane glycoside derived from ginsenoside Rb-3[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2005,53(2):177-179.
APA He, KJ,Liu, Y,Yang, Y,Li, P,&Yang, L.(2005).A dammarane glycoside derived from ginsenoside Rb-3.CHEMICAL & PHARMACEUTICAL BULLETIN,53(2),177-179.
MLA He, KJ,et al."A dammarane glycoside derived from ginsenoside Rb-3".CHEMICAL & PHARMACEUTICAL BULLETIN 53.2(2005):177-179.
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