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题名: In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms
作者: Zhang, CZ;  Wang, SX;  Zhang, Y;  Chen, JP;  Liang, XM
关键词: phytoestrogens ;  hormone replacement therapy ;  Chinese medicine ;  Saccharomyces cerevisiae
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2005-04-26
DOI: 10.1016/j.jep.2005.01.033
卷: 98, 期:3, 页:295-300
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: The estrogenic activity of 70% EtOH extracts of 32 traditional Chinese medicinal plants, selected according to their reported efficacy for the treatment of menopausal symptoms, was assessed using a recombinant yeast system with both a human estrogen receptor expression plasmid and a reporter plasmid. Among them, 11 (34%) species proved to be active. Polygonum to cuspidatum had the highest estrogenic relative potency (RP) (3.28 x 10(-3)), followed by Rheum palmatum (3.85 x 10(-4)), Cassia obtusifolio (3.49 x 10(-4)), Polygonum multiflorum (2.87 x 10(-4)), Epimedium brevicormum (2.30 x 10(-4)), Psoralea corylifolia (1.90 x 10(-4)), Cynomorium songaricum (1.78 x 10(-4)), Belamcanda chinensis (1.26 x 10(-4)). Scutellaria baicalensis (8.77 x 10(-5)), Astragalus membranaceus (8.47 x 10(-5)) and Puerario lobata (6.17 x 10(-5)). The EC50 value of 17 beta-estradiol used as the positive control was 0.205 +/- 0.025 ng/ml (RP = 100). This study gave support to the reported efficacy of Chinese medicines used for hormone replacement therapy. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
关键词[WOS]: SACCHAROMYCES-CEREVISIAE ;  YEAST ;  PHYTOESTROGENS ;  RECEPTOR ;  SCREEN
语种: 英语
WOS记录号: WOS:000228688300010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/139781
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
2.Coll Bio & Food Technol, Dalian Inst Light Ind, Dalian 116034, Peoples R China

Recommended Citation:
Zhang, CZ,Wang, SX,Zhang, Y,et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms[J]. JOURNAL OF ETHNOPHARMACOLOGY,2005,98(3):295-300.
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