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Readily available sulfamide-amine alcohols for enantioselective phenylacetylene addition to aldehydes in the absence of Ti(O(i)Pre)(4)
Mao, JC; Wan, BS; Wu, F; Lu, SW
刊名CHIRALITY
2005-05-15
DOI10.1002/chir.20165
17期:5页:245-249
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]AROMATIC-ALDEHYDES ; PROPARGYLIC ALCOHOLS ; ALKYNE ADDITIONS ; LIGAND ; ALKYNYLATION ; BINOL ; DIALKYLZINCS
英文摘要Ephedrine-derived sulfamide-amine alcohol 3 was found to be an effective catalyst for the asymmetric phenylacetylene addition to aldehydes at room temperature without using Ti((OPr)-Pr-i)(4) and Zn(OTf)(2.) It afforded the propargylic alcohols in high yields (up to 99%) and good enantioselectivities (up to 84% ee), which were much higher than that based on N-methylephedrine under the same reaction conditions. Its weakly coordinative sulfonamide moiety of the ligand plays an important role for further acceleration and stereocontrol in the alkynylation. (c) 2005 Wiley-Liss, Inc.
语种英语
WOS记录号WOS:000228825400002
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139786
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
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GB/T 7714
Mao, JC,Wan, BS,Wu, F,et al. Readily available sulfamide-amine alcohols for enantioselective phenylacetylene addition to aldehydes in the absence of Ti(O(i)Pre)(4)[J]. CHIRALITY,2005,17(5):245-249.
APA Mao, JC,Wan, BS,Wu, F,&Lu, SW.(2005).Readily available sulfamide-amine alcohols for enantioselective phenylacetylene addition to aldehydes in the absence of Ti(O(i)Pre)(4).CHIRALITY,17(5),245-249.
MLA Mao, JC,et al."Readily available sulfamide-amine alcohols for enantioselective phenylacetylene addition to aldehydes in the absence of Ti(O(i)Pre)(4)".CHIRALITY 17.5(2005):245-249.
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