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Chiral separation of 1,1 '-bi-2-naphthol and its analogue on molecular imprinting monolithic columns by HPLC
Ou, JJ; Tang, SW; Zou, HF
KeywordChiral Separation 1 Molecular Imprinting Polymer 1 '-bi-2-naphthol Monolithic Column 5 5 ' 6 6 ' 7 7 ' 8 8 '-octahydro-1 1 '-bi-2-naphthol
Source PublicationJOURNAL OF SEPARATION SCIENCE
2005-11-01
DOI10.1002/jssc.200500165
Volume28Issue:17Pages:2282-2287
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordCAPILLARY ELECTROCHROMATOGRAPHY ; ENANTIOMER SEPARATION ; STATIONARY PHASES ; MOBILE PHASES ; POLYMERS ; RECOGNITION ; SELECTIVITY ; DIASTEREOMERS ; RESOLUTION ; RETENTION
AbstractTwo molecular imprinting polymer (MIP) monolithic columns with (S)-(-)-1,1'-bi-2-naphthol and (R)-(+)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol as the templating molecules, respectively, have been prepared by in situ polymerization using 4-vinylpyridine and ethylene dimethacrylate as functional monomer and cross-linker, respectively. The columns with good flow-through properties were obtained by changing the molar ratio of the functional monomer and the template molecule. The effects of mobile-phase composition on separation of enantiomers were systematically investigated. The results indicate that hydrophobic interaction in aqueous solution and hydrogen-bonding interaction in ACN between the enantiomers and polymers could play important roles in the retention and resolution. The effects of chromatographic conditions, such as flow rate, column temperature, sample loading, on the enantioseparation were also studied. Further, these two MIP columns show a cross-reactivity.
Language英语
WOS IDWOS:000233679200007
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/139914
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Ou, JJ,Tang, SW,Zou, HF. Chiral separation of 1,1 '-bi-2-naphthol and its analogue on molecular imprinting monolithic columns by HPLC[J]. JOURNAL OF SEPARATION SCIENCE,2005,28(17):2282-2287.
APA Ou, JJ,Tang, SW,&Zou, HF.(2005).Chiral separation of 1,1 '-bi-2-naphthol and its analogue on molecular imprinting monolithic columns by HPLC.JOURNAL OF SEPARATION SCIENCE,28(17),2282-2287.
MLA Ou, JJ,et al."Chiral separation of 1,1 '-bi-2-naphthol and its analogue on molecular imprinting monolithic columns by HPLC".JOURNAL OF SEPARATION SCIENCE 28.17(2005):2282-2287.
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