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Characterization of small-molecule-biomicromolecule interactions: From simple to complex
Tian, RJ; Xu, SY; Lei, XY; Jin, WH; Ye, ML; Zou, HF
关键词Analytical Methodologies Library Screening Multiple Recognition Systems Simple Ligand-receptor Binding Small-molecule-biomacromolecule Interaction
刊名TRAC-TRENDS IN ANALYTICAL CHEMISTRY
2005-10-01
DOI10.1016/j.trac.2005.03.018
24期:9页:810-825
收录类别SCI
文章类型Review
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]HUMAN SERUM-ALBUMIN ; IONIZATION MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; AFFINITY CAPILLARY-ELECTROPHORESIS ; CDNA-PHAGE DISPLAY ; IMMOBILIZED-ENZYME REACTOR ; SURFACE-PLASMON RESONANCE ; DISSOCIATION-CONSTANTS ; COMPETITIVE-BINDING ; STATIONARY PHASES
英文摘要The interactions between small molecules and biomacromolecules constitute one of the most important parts of interconnected biological networks. To understand the recognition mechanisms of these interactions is of vital importance for characterizing the expression and the function of related biomacromolecules and further discovering drug candidates for the pharmaceutical industry and biomarkers for clinical diagnosis. Here, we summarize the general methodology used in these studies, mainly including chromatographic, electromigration and mass spectrometric methods. We present the latest applications of these methods for elucidating simple binding of plasma protein, enzyme, receptor and DNA/RNA with small molecules. We also present recognition studies based on multi-component systems (e.g., phage display, oligonucleotides, chemiproteomics and traditional Chinese medicines), which should be more challenging in both analytical tools and methodology and the function of biological systems. (c) 2005 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000232970400010
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被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/139931
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
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GB/T 7714
Tian, RJ,Xu, SY,Lei, XY,et al. Characterization of small-molecule-biomicromolecule interactions: From simple to complex[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2005,24(9):810-825.
APA Tian, RJ,Xu, SY,Lei, XY,Jin, WH,Ye, ML,&Zou, HF.(2005).Characterization of small-molecule-biomicromolecule interactions: From simple to complex.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,24(9),810-825.
MLA Tian, RJ,et al."Characterization of small-molecule-biomicromolecule interactions: From simple to complex".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 24.9(2005):810-825.
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