DICP OpenIR
Characterization of small-molecule-biomicromolecule interactions: From simple to complex
Tian, RJ; Xu, SY; Lei, XY; Jin, WH; Ye, ML; Zou, HF
KeywordAnalytical Methodologies Library Screening Multiple Recognition Systems Simple Ligand-receptor Binding Small-molecule-biomacromolecule Interaction
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
2005-10-01
DOI10.1016/j.trac.2005.03.018
Volume24Issue:9Pages:810-825
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordHUMAN SERUM-ALBUMIN ; IONIZATION MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; AFFINITY CAPILLARY-ELECTROPHORESIS ; CDNA-PHAGE DISPLAY ; IMMOBILIZED-ENZYME REACTOR ; SURFACE-PLASMON RESONANCE ; DISSOCIATION-CONSTANTS ; COMPETITIVE-BINDING ; STATIONARY PHASES
AbstractThe interactions between small molecules and biomacromolecules constitute one of the most important parts of interconnected biological networks. To understand the recognition mechanisms of these interactions is of vital importance for characterizing the expression and the function of related biomacromolecules and further discovering drug candidates for the pharmaceutical industry and biomarkers for clinical diagnosis. Here, we summarize the general methodology used in these studies, mainly including chromatographic, electromigration and mass spectrometric methods. We present the latest applications of these methods for elucidating simple binding of plasma protein, enzyme, receptor and DNA/RNA with small molecules. We also present recognition studies based on multi-component systems (e.g., phage display, oligonucleotides, chemiproteomics and traditional Chinese medicines), which should be more challenging in both analytical tools and methodology and the function of biological systems. (c) 2005 Elsevier Ltd. All rights reserved.
Language英语
WOS IDWOS:000232970400010
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/139931
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Tian, RJ,Xu, SY,Lei, XY,et al. Characterization of small-molecule-biomicromolecule interactions: From simple to complex[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2005,24(9):810-825.
APA Tian, RJ,Xu, SY,Lei, XY,Jin, WH,Ye, ML,&Zou, HF.(2005).Characterization of small-molecule-biomicromolecule interactions: From simple to complex.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,24(9),810-825.
MLA Tian, RJ,et al."Characterization of small-molecule-biomicromolecule interactions: From simple to complex".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 24.9(2005):810-825.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tian, RJ]'s Articles
[Xu, SY]'s Articles
[Lei, XY]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tian, RJ]'s Articles
[Xu, SY]'s Articles
[Lei, XY]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tian, RJ]'s Articles
[Xu, SY]'s Articles
[Lei, XY]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.