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题名: Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings
作者: Liu, Dan;  Zhou, Jiang;  Li, Huihui;  Zheng, Bo;  Yuan, Gu
关键词: DNA cleaving activity ;  ESI-mass spectrometry ;  site-selective DNA cleavage
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2006-10-01
DOI: 10.1016/j.bmcl.2006.07.049
卷: 16, 期:19, 页:5032-5035
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: A novel conjugate of 3-Clip-Phen and polyamide containing three N-methylimidazole (Im) rings was synthesized for the targeting human telomeric repeat of 5'-TTAGGG-3', and the DNA cleaving activity and the sequence selectivity of the complex of copper-conjugate were confirmed by electrospray ionization mass spectrometry. (c) 2006 Elsevier Ltd. All rights reserved.
关键词[WOS]: TELOMERASE ACTIVITY ;  BINDING ;  CANCER ;  CELLS
语种: 英语
WOS记录号: WOS:000240615400010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140061
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Peking Univ, Proteom Lab, Med & Hlth Analyt Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Dan,Zhou, Jiang,Li, Huihui,et al. Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(19):5032-5035.
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