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Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings
Liu, Dan; Zhou, Jiang; Li, Huihui; Zheng, Bo; Yuan, Gu
关键词Dna Cleaving Activity Esi-mass Spectrometry Site-selective Dna Cleavage
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2006-10-01
DOI10.1016/j.bmcl.2006.07.049
16期:19页:5032-5035
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]TELOMERASE ACTIVITY ; BINDING ; CANCER ; CELLS
英文摘要A novel conjugate of 3-Clip-Phen and polyamide containing three N-methylimidazole (Im) rings was synthesized for the targeting human telomeric repeat of 5'-TTAGGG-3', and the DNA cleaving activity and the sequence selectivity of the complex of copper-conjugate were confirmed by electrospray ionization mass spectrometry. (c) 2006 Elsevier Ltd. All rights reserved.
语种英语
WOS记录号WOS:000240615400010
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140061
专题中国科学院大连化学物理研究所
作者单位1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Peking Univ, Proteom Lab, Med & Hlth Analyt Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Liu, Dan,Zhou, Jiang,Li, Huihui,et al. Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(19):5032-5035.
APA Liu, Dan,Zhou, Jiang,Li, Huihui,Zheng, Bo,&Yuan, Gu.(2006).Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(19),5032-5035.
MLA Liu, Dan,et al."Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.19(2006):5032-5035.
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