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题名: (S)-ibuprofen-imprinted polymers incorporating gamma-methacryloxypropyltrimethoxysilane for CEC separation of ibuprofen enantiomers
作者: Deng, Qi-Liang;  Lun, Zhi-Hong;  Gao, Ru-Yu;  Zhang, Li-Hua;  Zhang, Wei-Bing;  Zhang, Yu-Kui
关键词: capillary electrochromatography ;  chiral recognition ;  ibuprofen ;  molecularly imprinted polymer
刊名: ELECTROPHORESIS
发表日期: 2006-11-01
DOI: 10.1002/elps.200600180
卷: 27, 期:21, 页:4351-4358
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: In this report, a novel preparation method of molecularly imprinted polymers (MIPs) for CEC was developed. Molecularly imprinted monolithic columns for (S)-ibuprofen were prepared and evaluated, in which charged entities responsible for establishing EOF have been derived from gamma-methacryloxypropyltrimethoxysilane (gamma-MAPS), which was hydrolyzed following copolymerization with 4-vinylpyridine (4-VPY) and ethylene glycol dimethacrylate (EDMA). The EOF and molecular recognition of the stationary phase were investigated in aqueous and nonaqueous media, respectively. The experimental results indicated that the material showed a reasonably stable EOF and the prepared separation materials were capable of separating racemic ibuprofen, a task that could not be accomplished by MIPs prepared in parallel, using methacrylic acid (MAA) as a functional monomer. The efficiency at pH 3.2 for the first-eluted enantiomer and the last-eluted enantiomer (the imprinted analyte) were 128 700 and 2100 plates/m, respectively.
关键词[WOS]: MOLECULARLY IMPRINTED POLYMERS ;  SELECTIVE STATIONARY PHASES ;  CAPILLARY ELECTROCHROMATOGRAPHY ;  LIQUID-CHROMATOGRAPHY ;  ELECTROPHORESIS ;  RECOGNITION ;  COATINGS
语种: 英语
WOS记录号: WOS:000242222500027
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140130
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, State Key Lab Element Organ Chem, Inst Element Organ Chem, Tianjin 300071, Peoples R China
2.Tianjin Univ Sci & Technol, Coll Sci, Tianjin, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Deng, Qi-Liang,Lun, Zhi-Hong,Gao, Ru-Yu,et al. (S)-ibuprofen-imprinted polymers incorporating gamma-methacryloxypropyltrimethoxysilane for CEC separation of ibuprofen enantiomers[J]. ELECTROPHORESIS,2006,27(21):4351-4358.
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