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Investigation of the concentration dependence of mass transfer coefficients in reversed-phase liquid chromatography
Hao, Weiqiang; Wang, Junde; Zhang, Xiangmin
KeywordCaffeine Chromatographic Models Frontal Analysis Reversed-phase Liquid Chromatography Surface Diffusivity
Source PublicationJOURNAL OF SEPARATION SCIENCE
2006-12-01
DOI10.1002/jssc.200600224
Volume29Issue:18Pages:2745-2758
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordBOVINE SERUM-ALBUMIN ; ANION-EXCHANGE CHROMATOGRAPHY ; FRONTAL ANALYSIS ; TRANSFER KINETICS ; BAND PROFILES ; NONLINEAR CHROMATOGRAPHY ; AFFINITY-CHROMATOGRAPHY ; 1-INDANOL ENANTIOMERS ; CELLULOSE TRIACETATE ; PEAK ASYMMETRY
AbstractIn order to investigate the concentration dependence of mass transfer coefficients in RPLC, experimental breakthrough curves obtained by staircase frontal analysis (FA) were fitted to the simplified models such as multiplate (MP) model, equilibrium dispersive (ED) model, and transport model, and the sophisticated models such as lumped pore diffusion (POR) model and general rate (GR) model. The NIP model was used to obtain the initial guesses of the parameters of the ED and the transport models. Then the best values were obtained by minimizing the differences between theoretical and experimental values with a nonlinear fitting procedure. The values of the parameters of the POR and the GR models can be calculated by using the expressions derived from the plate height equations, which was further validated by using the fitting method. It was found that the mass transfer coefficients would depend on the solute concentration. This can be ascribed to the surface diffusivity, which correlates with the concentration and is lumped into the mass transfer coefficients for both simplified and sophisticated models.
Language英语
WOS IDWOS:000243338800006
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140167
Collection中国科学院大连化学物理研究所
Affiliation1.Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Hao, Weiqiang,Wang, Junde,Zhang, Xiangmin. Investigation of the concentration dependence of mass transfer coefficients in reversed-phase liquid chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2006,29(18):2745-2758.
APA Hao, Weiqiang,Wang, Junde,&Zhang, Xiangmin.(2006).Investigation of the concentration dependence of mass transfer coefficients in reversed-phase liquid chromatography.JOURNAL OF SEPARATION SCIENCE,29(18),2745-2758.
MLA Hao, Weiqiang,et al."Investigation of the concentration dependence of mass transfer coefficients in reversed-phase liquid chromatography".JOURNAL OF SEPARATION SCIENCE 29.18(2006):2745-2758.
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