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题名: Investigation of the concentration dependence of mass transfer coefficients in reversed-phase liquid chromatography
作者: Hao, Weiqiang;  Wang, Junde;  Zhang, Xiangmin
关键词: caffeine ;  chromatographic models ;  frontal analysis ;  reversed-phase liquid chromatography ;  surface diffusivity
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2006-12-01
DOI: 10.1002/jssc.200600224
卷: 29, 期:18, 页:2745-2758
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: In order to investigate the concentration dependence of mass transfer coefficients in RPLC, experimental breakthrough curves obtained by staircase frontal analysis (FA) were fitted to the simplified models such as multiplate (MP) model, equilibrium dispersive (ED) model, and transport model, and the sophisticated models such as lumped pore diffusion (POR) model and general rate (GR) model. The NIP model was used to obtain the initial guesses of the parameters of the ED and the transport models. Then the best values were obtained by minimizing the differences between theoretical and experimental values with a nonlinear fitting procedure. The values of the parameters of the POR and the GR models can be calculated by using the expressions derived from the plate height equations, which was further validated by using the fitting method. It was found that the mass transfer coefficients would depend on the solute concentration. This can be ascribed to the surface diffusivity, which correlates with the concentration and is lumped into the mass transfer coefficients for both simplified and sophisticated models.
关键词[WOS]: BOVINE SERUM-ALBUMIN ;  ANION-EXCHANGE CHROMATOGRAPHY ;  FRONTAL ANALYSIS ;  TRANSFER KINETICS ;  BAND PROFILES ;  NONLINEAR CHROMATOGRAPHY ;  AFFINITY-CHROMATOGRAPHY ;  1-INDANOL ENANTIOMERS ;  CELLULOSE TRIACETATE ;  PEAK ASYMMETRY
语种: 英语
WOS记录号: WOS:000243338800006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140167
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Hao, Weiqiang,Wang, Junde,Zhang, Xiangmin. Investigation of the concentration dependence of mass transfer coefficients in reversed-phase liquid chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2006,29(18):2745-2758.
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