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题名: Distribution of the functional MDRIC3435T polymorphism in the Han population of China
作者: Li, YH;  Wang, YH;  Sun, J;  Li, Y;  Yang, L
关键词: p-glycoprotein (P-gp) ;  MDR1 ;  single nucleotide polymorphism (SNP) ;  3435C > T
刊名: SWISS MEDICAL WEEKLY
发表日期: 2006-06-10
卷: 136, 期:23-24, 页:377-382
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
英文摘要: Principles: 3435C > T, a single nucleotide polymorphism (SNP) in exon 26 of the MDRI gene, is linked to the variability of P-gp expression and function among different individuals. It was found that ethnic differences exist in the polymorphism of the MDR1(C3435T) gene. However, the distribution of 3435C > T genotypes in the Chinese Han population is not clear up till now.
关键词[WOS]: MDR1 GENE POLYMORPHISM ;  SINGLE-NUCLEOTIDE POLYMORPHISMS ;  ACUTE LYMPHOBLASTIC-LEUKEMIA ;  HEALTHY JAPANESE SUBJECTS ;  MESSENGER-RNA EXPRESSION ;  P-GLYCOPROTEIN ;  C3435T POLYMORPHISM ;  DRUG TRANSPORTER ;  ULCERATIVE-COLITIS ;  SEQUENCE VARIATIONS
语种: 英语
WOS记录号: WOS:000238594800004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140196
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 2, Dalian, Peoples R China

Recommended Citation:
Li, YH,Wang, YH,Sun, J,et al. Distribution of the functional MDRIC3435T polymorphism in the Han population of China[J]. SWISS MEDICAL WEEKLY,2006,136(23-24):377-382.
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