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题名: Toxicity of cationic lipids and cationic polymers in gene delivery
作者: Lv, Hongtao;  Zhang, Shubiao;  Wang, Bing;  Cui, Shaohui;  Yan, Jie
关键词: gene therapy ;  non-viral vector ;  cationic lipids ;  cationic polymers ;  toxicity
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2006-08-10
DOI: 10.1016/j.jconrel.2006.04.014
卷: 114, 期:1, 页:100-109
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. They hold the promise to replace viral vectors to be used in clinic. However, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. For overcoming the problem, many new cationic compounds have been developed. This article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. We evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: LOW-MOLECULAR-WEIGHT ;  MEDIATED DNA-TRANSFECTION ;  PROTEIN-KINASE-C ;  IN-VITRO ;  NONVIRAL VECTOR ;  LIPOSOME COMPLEXES ;  MAMMALIAN-CELLS ;  PHYSICOCHEMICAL PROPERTIES ;  IMMUNOMODULATORY ACTIVITY ;  CHOLESTEROL DERIVATIVES
语种: 英语
WOS记录号: WOS:000240052500010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140235
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Nationalities Univ, Dept Chem Engn, Coll Life Sci, Dalian 116600, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
3.Sichuan Univ Sci & Engn, Dept Mat Sci & Chem Engn, Zigong 643000, Sichuan, Peoples R China

Recommended Citation:
Lv, Hongtao,Zhang, Shubiao,Wang, Bing,et al. Toxicity of cationic lipids and cationic polymers in gene delivery[J]. JOURNAL OF CONTROLLED RELEASE,2006,114(1):100-109.
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