DICP OpenIR
Toxicity of cationic lipids and cationic polymers in gene delivery
Lv, Hongtao; Zhang, Shubiao; Wang, Bing; Cui, Shaohui; Yan, Jie
关键词Gene Therapy Non-viral Vector Cationic Lipids Cationic Polymers Toxicity
刊名JOURNAL OF CONTROLLED RELEASE
2006-08-10
DOI10.1016/j.jconrel.2006.04.014
114期:1页:100-109
收录类别SCI
文章类型Review
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]LOW-MOLECULAR-WEIGHT ; MEDIATED DNA-TRANSFECTION ; PROTEIN-KINASE-C ; IN-VITRO ; NONVIRAL VECTOR ; LIPOSOME COMPLEXES ; MAMMALIAN-CELLS ; PHYSICOCHEMICAL PROPERTIES ; IMMUNOMODULATORY ACTIVITY ; CHOLESTEROL DERIVATIVES
英文摘要Gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. They hold the promise to replace viral vectors to be used in clinic. However, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. For overcoming the problem, many new cationic compounds have been developed. This article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. We evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds. (c) 2006 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000240052500010
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140235
专题中国科学院大连化学物理研究所
作者单位1.Dalian Nationalities Univ, Dept Chem Engn, Coll Life Sci, Dalian 116600, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
3.Sichuan Univ Sci & Engn, Dept Mat Sci & Chem Engn, Zigong 643000, Sichuan, Peoples R China
推荐引用方式
GB/T 7714
Lv, Hongtao,Zhang, Shubiao,Wang, Bing,et al. Toxicity of cationic lipids and cationic polymers in gene delivery[J]. JOURNAL OF CONTROLLED RELEASE,2006,114(1):100-109.
APA Lv, Hongtao,Zhang, Shubiao,Wang, Bing,Cui, Shaohui,&Yan, Jie.(2006).Toxicity of cationic lipids and cationic polymers in gene delivery.JOURNAL OF CONTROLLED RELEASE,114(1),100-109.
MLA Lv, Hongtao,et al."Toxicity of cationic lipids and cationic polymers in gene delivery".JOURNAL OF CONTROLLED RELEASE 114.1(2006):100-109.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lv, Hongtao]的文章
[Zhang, Shubiao]的文章
[Wang, Bing]的文章
百度学术
百度学术中相似的文章
[Lv, Hongtao]的文章
[Zhang, Shubiao]的文章
[Wang, Bing]的文章
必应学术
必应学术中相似的文章
[Lv, Hongtao]的文章
[Zhang, Shubiao]的文章
[Wang, Bing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。