DICP OpenIR
Toxicity of cationic lipids and cationic polymers in gene delivery
Lv, Hongtao; Zhang, Shubiao; Wang, Bing; Cui, Shaohui; Yan, Jie
KeywordGene Therapy Non-viral Vector Cationic Lipids Cationic Polymers Toxicity
Source PublicationJOURNAL OF CONTROLLED RELEASE
2006-08-10
DOI10.1016/j.jconrel.2006.04.014
Volume114Issue:1Pages:100-109
Indexed BySCI
SubtypeReview
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordLOW-MOLECULAR-WEIGHT ; MEDIATED DNA-TRANSFECTION ; PROTEIN-KINASE-C ; IN-VITRO ; NONVIRAL VECTOR ; LIPOSOME COMPLEXES ; MAMMALIAN-CELLS ; PHYSICOCHEMICAL PROPERTIES ; IMMUNOMODULATORY ACTIVITY ; CHOLESTEROL DERIVATIVES
AbstractGene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. They hold the promise to replace viral vectors to be used in clinic. However, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. For overcoming the problem, many new cationic compounds have been developed. This article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. We evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds. (c) 2006 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000240052500010
Citation statistics
Cited Times:1104[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140235
Collection中国科学院大连化学物理研究所
Affiliation1.Dalian Nationalities Univ, Dept Chem Engn, Coll Life Sci, Dalian 116600, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
3.Sichuan Univ Sci & Engn, Dept Mat Sci & Chem Engn, Zigong 643000, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Lv, Hongtao,Zhang, Shubiao,Wang, Bing,et al. Toxicity of cationic lipids and cationic polymers in gene delivery[J]. JOURNAL OF CONTROLLED RELEASE,2006,114(1):100-109.
APA Lv, Hongtao,Zhang, Shubiao,Wang, Bing,Cui, Shaohui,&Yan, Jie.(2006).Toxicity of cationic lipids and cationic polymers in gene delivery.JOURNAL OF CONTROLLED RELEASE,114(1),100-109.
MLA Lv, Hongtao,et al."Toxicity of cationic lipids and cationic polymers in gene delivery".JOURNAL OF CONTROLLED RELEASE 114.1(2006):100-109.
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