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| Toxicity of cationic lipids and cationic polymers in gene delivery | |
| Lv, Hongtao; Zhang, Shubiao; Wang, Bing; Cui, Shaohui; Yan, Jie | |
| Keyword | Gene Therapy Non-viral Vector Cationic Lipids Cationic Polymers Toxicity |
| Source Publication | JOURNAL OF CONTROLLED RELEASE
 |
| 2006-08-10 | |
| DOI | 10.1016/j.jconrel.2006.04.014 |
| Volume | 114Issue:1Pages:100-109 |
| Indexed By | SCI |
| Subtype | Review |
| WOS Headings | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| WOS Subject | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
| WOS Keyword | LOW-MOLECULAR-WEIGHT ; MEDIATED DNA-TRANSFECTION ; PROTEIN-KINASE-C ; IN-VITRO ; NONVIRAL VECTOR ; LIPOSOME COMPLEXES ; MAMMALIAN-CELLS ; PHYSICOCHEMICAL PROPERTIES ; IMMUNOMODULATORY ACTIVITY ; CHOLESTEROL DERIVATIVES |
| Abstract | Gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. They hold the promise to replace viral vectors to be used in clinic. However, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. For overcoming the problem, many new cationic compounds have been developed. This article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. We evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds. (c) 2006 Elsevier B.V. All rights reserved. |
| Language | 英语 |
| WOS ID | WOS:000240052500010 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://cas-ir.dicp.ac.cn/handle/321008/140235 |
| Collection | 中国科学院大连化学物理研究所 |
| Affiliation | 1.Dalian Nationalities Univ, Dept Chem Engn, Coll Life Sci, Dalian 116600, Liaoning, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China 3.Sichuan Univ Sci & Engn, Dept Mat Sci & Chem Engn, Zigong 643000, Sichuan, Peoples R China |
| Recommended Citation GB/T 7714 | Lv, Hongtao,Zhang, Shubiao,Wang, Bing,et al. Toxicity of cationic lipids and cationic polymers in gene delivery[J]. JOURNAL OF CONTROLLED RELEASE,2006,114(1):100-109. |
| APA | Lv, Hongtao,Zhang, Shubiao,Wang, Bing,Cui, Shaohui,&Yan, Jie.(2006).Toxicity of cationic lipids and cationic polymers in gene delivery.JOURNAL OF CONTROLLED RELEASE,114(1),100-109. |
| MLA | Lv, Hongtao,et al."Toxicity of cationic lipids and cationic polymers in gene delivery".JOURNAL OF CONTROLLED RELEASE 114.1(2006):100-109. |
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