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题名: Evaluation of binding selectivity of a polyamide probe to single base-pair different DNA in A center dot T-rich region by electrospray ionization mass spectrometry
作者: Li, Huihui;  Yuan, Gu
刊名: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
发表日期: 2006-12-01
DOI: 10.1016/j.jasms.2006.07.028
卷: 17, 期:12, 页:1742-1748
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Analytical ;  Chemistry, Physical ;  Spectroscopy
研究领域[WOS]: Chemistry ;  Spectroscopy
英文摘要: In this study, electrospray ionization mass spectrometry (ESI-MS) was used for the evaluation of the binding selectivity of a polyamide probe to single-base pair different DNA in an A-T-rich region. In this procedure, Delta Ir(ds(n)) was introduced as a parameter to compare the binding affinities of the polyamides with the duplex DNA. The results show that ESI-MS is a very useful tool for analysis of binding selectivity of a polyamide probe to single-base pair different DNA.
关键词[WOS]: DOUBLE-STRANDED OLIGODEOXYNUCLEOTIDES ;  MINOR-GROOVE ;  NONCOVALENT COMPLEXES ;  RECOGNIZING POLYAMIDES ;  SEQUENCE SELECTIVITY ;  N-METHYLIMIDAZOLE ;  GENE-EXPRESSION ;  RECOGNITION ;  DRUGS ;  AFFINITY
语种: 英语
WOS记录号: WOS:000242736200016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140285
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Li, Huihui,Yuan, Gu. Evaluation of binding selectivity of a polyamide probe to single base-pair different DNA in A center dot T-rich region by electrospray ionization mass spectrometry[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2006,17(12):1742-1748.
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