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Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis
Zhao, Xinjie; Wang, Wenzhao; Wang, Jiangshan; Yang, Jun; Xu, Guowang
关键词Biomarkers Metabolic Profiling Metabonomics Nucleosides Uplc-tof Ms
刊名JOURNAL OF SEPARATION SCIENCE
2006-11-01
DOI10.1002/jssc.200600157
29期:16页:2444-2451
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; TOF MASS-SPECTROMETRY ; MODIFIED NUCLEOSIDES ; CAPILLARY-ELECTROPHORESIS ; METABONOMICS ; HEPATITIS ; TOXICITY ; GENDER ; TOOL
英文摘要Nucleosides are an important class of metabolites and have been investigated as potential tumor biomarkers. A method based on ultra performance liquid chromatography (UPLC)-TOF MS was developed to analyze urinary nucleosides and other metabolites with cis-diol structure to distinguish between cancer patients and healthy persons and compare the results with those obtained by HPLC. The data showed that the UPLC method used about one third of the time required by HPLC and achieved a much better chromatographic resolution and increased sensitivity, the number of peaks detected by UV being 79 and 94 for HPLC and UPLC, respectively. With UPLC-TOF MS, more information was obtained about metabolites, the separation of cancer patients from healthy persons was significantly improved, and more potential biomarkers were found. The method based on UPLC-TOF MS is a powerful technique for the study of metabolite profiles.
语种英语
WOS记录号WOS:000242242300005
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140304
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Liaoning, Peoples R China
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GB/T 7714
Zhao, Xinjie,Wang, Wenzhao,Wang, Jiangshan,et al. Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis[J]. JOURNAL OF SEPARATION SCIENCE,2006,29(16):2444-2451.
APA Zhao, Xinjie,Wang, Wenzhao,Wang, Jiangshan,Yang, Jun,&Xu, Guowang.(2006).Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis.JOURNAL OF SEPARATION SCIENCE,29(16),2444-2451.
MLA Zhao, Xinjie,et al."Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis".JOURNAL OF SEPARATION SCIENCE 29.16(2006):2444-2451.
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