DICP OpenIR
Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis
Zhao, Xinjie; Wang, Wenzhao; Wang, Jiangshan; Yang, Jun; Xu, Guowang
KeywordBiomarkers Metabolic Profiling Metabonomics Nucleosides Uplc-tof Ms
Source PublicationJOURNAL OF SEPARATION SCIENCE
2006-11-01
DOI10.1002/jssc.200600157
Volume29Issue:16Pages:2444-2451
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; TOF MASS-SPECTROMETRY ; MODIFIED NUCLEOSIDES ; CAPILLARY-ELECTROPHORESIS ; METABONOMICS ; HEPATITIS ; TOXICITY ; GENDER ; TOOL
AbstractNucleosides are an important class of metabolites and have been investigated as potential tumor biomarkers. A method based on ultra performance liquid chromatography (UPLC)-TOF MS was developed to analyze urinary nucleosides and other metabolites with cis-diol structure to distinguish between cancer patients and healthy persons and compare the results with those obtained by HPLC. The data showed that the UPLC method used about one third of the time required by HPLC and achieved a much better chromatographic resolution and increased sensitivity, the number of peaks detected by UV being 79 and 94 for HPLC and UPLC, respectively. With UPLC-TOF MS, more information was obtained about metabolites, the separation of cancer patients from healthy persons was significantly improved, and more potential biomarkers were found. The method based on UPLC-TOF MS is a powerful technique for the study of metabolite profiles.
Language英语
WOS IDWOS:000242242300005
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140304
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Xinjie,Wang, Wenzhao,Wang, Jiangshan,et al. Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis[J]. JOURNAL OF SEPARATION SCIENCE,2006,29(16):2444-2451.
APA Zhao, Xinjie,Wang, Wenzhao,Wang, Jiangshan,Yang, Jun,&Xu, Guowang.(2006).Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis.JOURNAL OF SEPARATION SCIENCE,29(16),2444-2451.
MLA Zhao, Xinjie,et al."Urinary profiling investigation of metabollites with cis-diol structure from cancer patients based on UPLC-MS and HPLC-MS as well as multivariate statistical analysis".JOURNAL OF SEPARATION SCIENCE 29.16(2006):2444-2451.
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