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Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes
Liu, Y; Ma, H; Zhang, JW; Deng, MC; Yang, L
关键词Ginsenoside Hydrolysis Products Systemic Circulation Cytochrome P450
刊名PLANTA MEDICA
2006-02-01
DOI10.1055/s-2005-873197
72期:2页:126-131
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]HERB-DRUG INTERACTIONS ; IN-VITRO ; CATALYTIC-ACTIVITY ; METABOLISM ; SAPONINS ; IDENTIFICATION ; VARIABILITY ; ABSORPTION ; COMPONENTS ; EXCRETION
英文摘要For an oral herbal medicine, the components that can enter the systemic circulation may be the really effective components. In the present study, the effects on the human cytochrome P450 activities of ginsenoside Rb-1 and two hydrolysis products of 20(S)protopanaxatriol ginsenosides in humans, namely ginsenoside Rb-1 and F-1, which may reach the systemic circulation after oral administration of ginseng extract, were evaluated. Our results showed that Rb-1 exhibited no marked effects on the activities of human cytochrome P450, whereas Rh-1 and F, exhibited competitive inhibition of the activity of CYP3A4 with K-i values of 57.7 +/- 9.6 mu M and 67.8 +/- 16.2 mu M, respectively. F-1 also exhibited a weak- er inhibition of the activity of CYP2D6. Rh, exhibited a weak stimulation rather than an inhibition of the activity of CYP2E1. The degradation of ginsenosides in the gastrointestinal tract may play an important role in the ginseng-associated drug-drug interactions, but the effects might be not due to Rh-1 and F-1.
语种英语
WOS记录号WOS:000235565300005
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被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140317
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Dalian, Peoples R China
3.Liaoning Normal Univ, Coll Life Sci, Liaoning, Peoples R China
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GB/T 7714
Liu, Y,Ma, H,Zhang, JW,et al. Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes[J]. PLANTA MEDICA,2006,72(2):126-131.
APA Liu, Y,Ma, H,Zhang, JW,Deng, MC,&Yang, L.(2006).Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes.PLANTA MEDICA,72(2),126-131.
MLA Liu, Y,et al."Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes".PLANTA MEDICA 72.2(2006):126-131.
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