中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes
作者: Liu, Y;  Ma, H;  Zhang, JW;  Deng, MC;  Yang, L
关键词: ginsenoside ;  hydrolysis products ;  systemic circulation ;  cytochrome ;  P450
刊名: PLANTA MEDICA
发表日期: 2006-02-01
DOI: 10.1055/s-2005-873197
卷: 72, 期:2, 页:126-131
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: For an oral herbal medicine, the components that can enter the systemic circulation may be the really effective components. In the present study, the effects on the human cytochrome P450 activities of ginsenoside Rb-1 and two hydrolysis products of 20(S)protopanaxatriol ginsenosides in humans, namely ginsenoside Rb-1 and F-1, which may reach the systemic circulation after oral administration of ginseng extract, were evaluated. Our results showed that Rb-1 exhibited no marked effects on the activities of human cytochrome P450, whereas Rh-1 and F, exhibited competitive inhibition of the activity of CYP3A4 with K-i values of 57.7 +/- 9.6 mu M and 67.8 +/- 16.2 mu M, respectively. F-1 also exhibited a weak- er inhibition of the activity of CYP2D6. Rh, exhibited a weak stimulation rather than an inhibition of the activity of CYP2E1. The degradation of ginsenosides in the gastrointestinal tract may play an important role in the ginseng-associated drug-drug interactions, but the effects might be not due to Rh-1 and F-1.
关键词[WOS]: HERB-DRUG INTERACTIONS ;  IN-VITRO ;  CATALYTIC-ACTIVITY ;  METABOLISM ;  SAPONINS ;  IDENTIFICATION ;  VARIABILITY ;  ABSORPTION ;  COMPONENTS ;  EXCRETION
语种: 英语
WOS记录号: WOS:000235565300005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140317
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Dalian, Peoples R China
3.Liaoning Normal Univ, Coll Life Sci, Liaoning, Peoples R China

Recommended Citation:
Liu, Y,Ma, H,Zhang, JW,et al. Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes[J]. PLANTA MEDICA,2006,72(2):126-131.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Liu, Y]'s Articles
 [Ma, H]'s Articles
 [Zhang, JW]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Liu, Y]‘s Articles
 [Ma, H]‘s Articles
 [Zhang, JW]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace