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题名: Preparation and characteristics of floating-bioadhesive microcapsules containing clarithromycin
作者: Zheng Jian-Hua;  Liu Chao-Wu;  Bao De-Cai;  Zhao Yan-Jun;  Ma Xiao-Jun
关键词: clarithromycin ;  floating-bioadhesive microcapsules ;  in vitro floating characteristic ;  gastric residence characteristic ;  Helicobacter pylori
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2006-06-01
卷: 27, 期:6, 页:1182-1185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Floating-bioadhesive microcapsules containing clarithromycin were prepared by a combined method of emulsion solvent diffusion and internal/ion gelation for the treatment of Helicobacter pylori. Ethylcellulose microsphers(EMs) were prepared by the emulsion solvent diffusion method. EMs were coated with alginate and chitosan by the internal/ion gelation method to get alginate-ethylcellulose microcapsules (AM) and chitosan-alginate-ethylcellulose microcapsules(CAEMs). The drug efficiency and drug content of clarithromycin in CAEMs were determined to be 72.3%-78.2% and 7.1%-12.7%, respectively. CAM showed an obviously sustaining effect for more than 6 h in vitro, and more than 70% of CAM floated in acetate buffer solution for 8 h in vitro. Furthermore, the in vitro remaining percentage of CAEMs in the stomach 4 h after the administration was 60.5%. The results suggest that floating-bioadhesive microcapsules might be a promising drug delivery system for the treatment of Helicobacter pylori infection.
关键词[WOS]: IN-VITRO ;  MUCOADHESIVE MICROSPHERES ;  DRUG-DELIVERY ;  TRACT ;  VIVO
语种: 英语
WOS记录号: WOS:000238377500046
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140327
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
2.Bohai Univ, Coll Chem & Chem Engn, JinZhou 12100, Peoples R China

Recommended Citation:
Zheng Jian-Hua,Liu Chao-Wu,Bao De-Cai,et al. Preparation and characteristics of floating-bioadhesive microcapsules containing clarithromycin[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2006,27(6):1182-1185.
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