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题名: Study of conical columns with 10 degrees opening angle for preparative liquid chromatography
作者: Guan, WN;  Xu, F;  Tan, F;  Guan, YF
关键词: preparative liquid chromatography ;  conical column ;  column scale up ;  sample loadability
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2006-03-10
DOI: 10.1016/j.chroma.2006.01.042
卷: 1108, 期:2, 页:218-224
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The efficiency and sample capacity of conical liquid chromatographic columns with 10 degrees opening angle were studied at different ratio of cross section areas of inlet to outlet (A(in)/A(out)) and column dimension. As the A(in)/A(out) ratio changed from 4 to 2.25, the reduced plate height (h) was reduced and the h value decreased 12% when the column dimension was scaled up proportionally because of relatively smaller dead volume on both end of the column. Compared to cylindrical columns having corresponding lengths and volumes, the conical columns with 10 degrees opening angle were superior in column efficiency, resolution and the maximum peak concentration at column outlet; the loadability of conical column was improved 30-40% on injection volume and 50-60% on sample mass, respectively, over cylindrical columns. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE ;  PURIFICATION ;  EFFICIENCY ;  SCALE ;  PEAKS ;  FLOW
语种: 英语
WOS记录号: WOS:000235854900010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140329
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Analyt Chem & Microinstrumentat, Dalian 116023, Peoples R China

Recommended Citation:
Guan, WN,Xu, F,Tan, F,et al. Study of conical columns with 10 degrees opening angle for preparative liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2006,1108(2):218-224.
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