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Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)
Li, QR; Ma, J; Tan, L; Wang, C; Li, N; Li, YS; Xu, GW; Li, JS
KeywordPolyunsaurated Fatty Acids Docosahexaenoic Acid Il-2 Receptor Signaling Pathway Lipid Raft
Source PublicationSCIENCE IN CHINA SERIES C-LIFE SCIENCES
2006-02-01
DOI10.1007/s11427-005-0014-1
Volume49Issue:1Pages:63-72
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiology
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS KeywordPOLYUNSATURATED FATTY-ACIDS ; PROTEIN-TYROSINE KINASES ; PLASMA-MEMBRANE RAFTS ; GPI-MICRODOMAINS ; RECEPTOR ; LOCALIZATION ; ACTIVATION ; CELLS ; STATS ; TRANSDUCTION
AbstractRecent studies have shown that polyunsaturated fatty acids (PUFA) regulated the functions of membrane receptors in T cells and suppressed T cell-mediated immune responses. But the molecular mechanisms of immune regulation are not yet elucidated. Lipid rafts are plasma membrane microdomains, in which many receptors localized. The purpose of this study was to investigate the effect of DHA on IL-2R signaling pathway in lipid rafts. We isolated lipid rafts by discontinuous sucrose density gradient ultracentrifugation, and found that DHA could change the composition of lipid rafts and alter the distribution of key molecules of IL-2R signaling pathway, which transferred from lipid rafts to detergent-soluble membrane fractions. These results revealed that DHA treatment increased the proportion of polyunsaturated fatty acids especially n-3 polyunsaturated fatty acids in lipid rafts and changed the lipid environment of membrane microdomains in T cells. Compared with controls, DHA changed the localization of IL-2R, STAT5a and STAT5b in lipid rafts and suppressed the expression of JAK1, JAK3 and tyrosine phosphotyrosine in soluble membrane fractions. Summarily, this study concluded the effects of DHA on IL-2R signaling pathway in lipid rafts and explained the regulation of PUFAs in T cell-mediated immune responses.
Language英语
WOS IDWOS:000236156100008
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140358
Collection中国科学院大连化学物理研究所
Affiliation1.Gen Hosp Nanjing Command, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatogr R&A Ctr, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Li, QR,Ma, J,Tan, L,et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2006,49(1):63-72.
APA Li, QR.,Ma, J.,Tan, L.,Wang, C.,Li, N.,...&Li, JS.(2006).Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007).SCIENCE IN CHINA SERIES C-LIFE SCIENCES,49(1),63-72.
MLA Li, QR,et al."Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 49.1(2006):63-72.
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