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题名: Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)
作者: Li, QR;  Ma, J;  Tan, L;  Wang, C;  Li, N;  Li, YS;  Xu, GW;  Li, JS
关键词: polyunsaurated fatty acids ;  docosahexaenoic acid ;  IL-2 receptor signaling pathway ;  lipid raft
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
发表日期: 2006-02-01
DOI: 10.1007/s11427-005-0014-1
卷: 49, 期:1, 页:63-72
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
英文摘要: Recent studies have shown that polyunsaturated fatty acids (PUFA) regulated the functions of membrane receptors in T cells and suppressed T cell-mediated immune responses. But the molecular mechanisms of immune regulation are not yet elucidated. Lipid rafts are plasma membrane microdomains, in which many receptors localized. The purpose of this study was to investigate the effect of DHA on IL-2R signaling pathway in lipid rafts. We isolated lipid rafts by discontinuous sucrose density gradient ultracentrifugation, and found that DHA could change the composition of lipid rafts and alter the distribution of key molecules of IL-2R signaling pathway, which transferred from lipid rafts to detergent-soluble membrane fractions. These results revealed that DHA treatment increased the proportion of polyunsaturated fatty acids especially n-3 polyunsaturated fatty acids in lipid rafts and changed the lipid environment of membrane microdomains in T cells. Compared with controls, DHA changed the localization of IL-2R, STAT5a and STAT5b in lipid rafts and suppressed the expression of JAK1, JAK3 and tyrosine phosphotyrosine in soluble membrane fractions. Summarily, this study concluded the effects of DHA on IL-2R signaling pathway in lipid rafts and explained the regulation of PUFAs in T cell-mediated immune responses.
关键词[WOS]: POLYUNSATURATED FATTY-ACIDS ;  PROTEIN-TYROSINE KINASES ;  PLASMA-MEMBRANE RAFTS ;  GPI-MICRODOMAINS ;  RECEPTOR ;  LOCALIZATION ;  ACTIVATION ;  CELLS ;  STATS ;  TRANSDUCTION
语种: 英语
WOS记录号: WOS:000236156100008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140358
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Gen Hosp Nanjing Command, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatogr R&A Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Li, QR,Ma, J,Tan, L,et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2006,49(1):63-72.
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