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Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)
Li, QR; Ma, J; Tan, L; Wang, C; Li, N; Li, YS; Xu, GW; Li, JS
关键词Polyunsaurated Fatty Acids Docosahexaenoic Acid Il-2 Receptor Signaling Pathway Lipid Raft
刊名SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2006-02-01
DOI10.1007/s11427-005-0014-1
49期:1页:63-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]POLYUNSATURATED FATTY-ACIDS ; PROTEIN-TYROSINE KINASES ; PLASMA-MEMBRANE RAFTS ; GPI-MICRODOMAINS ; RECEPTOR ; LOCALIZATION ; ACTIVATION ; CELLS ; STATS ; TRANSDUCTION
英文摘要Recent studies have shown that polyunsaturated fatty acids (PUFA) regulated the functions of membrane receptors in T cells and suppressed T cell-mediated immune responses. But the molecular mechanisms of immune regulation are not yet elucidated. Lipid rafts are plasma membrane microdomains, in which many receptors localized. The purpose of this study was to investigate the effect of DHA on IL-2R signaling pathway in lipid rafts. We isolated lipid rafts by discontinuous sucrose density gradient ultracentrifugation, and found that DHA could change the composition of lipid rafts and alter the distribution of key molecules of IL-2R signaling pathway, which transferred from lipid rafts to detergent-soluble membrane fractions. These results revealed that DHA treatment increased the proportion of polyunsaturated fatty acids especially n-3 polyunsaturated fatty acids in lipid rafts and changed the lipid environment of membrane microdomains in T cells. Compared with controls, DHA changed the localization of IL-2R, STAT5a and STAT5b in lipid rafts and suppressed the expression of JAK1, JAK3 and tyrosine phosphotyrosine in soluble membrane fractions. Summarily, this study concluded the effects of DHA on IL-2R signaling pathway in lipid rafts and explained the regulation of PUFAs in T cell-mediated immune responses.
语种英语
WOS记录号WOS:000236156100008
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140358
专题中国科学院大连化学物理研究所
作者单位1.Gen Hosp Nanjing Command, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatogr R&A Ctr, Dalian 116011, Peoples R China
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Li, QR,Ma, J,Tan, L,et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2006,49(1):63-72.
APA Li, QR.,Ma, J.,Tan, L.,Wang, C.,Li, N.,...&Li, JS.(2006).Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007).SCIENCE IN CHINA SERIES C-LIFE SCIENCES,49(1),63-72.
MLA Li, QR,et al."Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts (Retracted article. See vol 50 pg 140, 2007)".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 49.1(2006):63-72.
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