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Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
Zhang, X.; Sun, Y. G.; Cheng, M. C.; Wang, Y. Q.; Xiao, H. B.; Liang, X. M.
关键词Isoflavonoid Glycoside Astragalus Mongholicus Liquid Chromatography Tandem Mass Spectrometry Plasma
刊名ANALYTICA CHIMICA ACTA
2007-10-29
DOI10.1016/j.aca.2007.09.033
602期:2页:252-258
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]ASTRAGALUS-MONGHOLICUS ; RADIX-ASTRAGALI
英文摘要A selective and sensitive liquid chromatography coupled with triple stage quadruple tandem mass spectrometry (HPLC/TSQ-MS/MS) was developed and validated for simultaneous quantification of calycosin-7-O-beta-D-glycoside (CCSG), formononetin-7-O-beta-D-glycoside (Ononin) and (6R,10R)-9,10-dimethoxypterocarpan-3-O-beta-D-glycoside (DPG) in rabbit plasma. Plasma samples were extracted with solid-phase extraction (SPE), separated on an Inertsil ODS-3 column and detected by tandem mass spectrometry with electrospray ionization (ESI) interface in positive selective reaction monitoring (SRM) mode. 3,7,8-Trimethoxy-xanthone-1-O-primaverose was used as internal standard (IS) for quantitative measurement. For each analyte, one major product ion was chosen and used for screening of it. Calibration curves were generated over the range of 2-1000 ng mL(-1) with the correlation coefficients greater than 0.99 by using a weighted (1/chi) least squares linear regression. The method had the lower limit quantification of 0.15, 0.21 and 0.19 for CCSG, Ononin and DPG, respectively, with precision less than 20%. The intra- and inter-day precisions ranged from 2.48 to 6.38% and 4.81 to 11.78% (R.S.D.%), respectively. This assay is suitable for determining the above three trace glycosides in rabbit plasma simultaneously and thus investigating the pharmacokinetics of glycosides from Astragalus mongholicus extract in rabbits. (C) 2007 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000250629800013
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140396
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Zhang, X.,Sun, Y. G.,Cheng, M. C.,et al. Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry[J]. ANALYTICA CHIMICA ACTA,2007,602(2):252-258.
APA Zhang, X.,Sun, Y. G.,Cheng, M. C.,Wang, Y. Q.,Xiao, H. B.,&Liang, X. M..(2007).Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.ANALYTICA CHIMICA ACTA,602(2),252-258.
MLA Zhang, X.,et al."Simultaneous quantification of three isoflavonoid glycosies in rabbit plasma after oral administration of Astraogalus mongholicus extract by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry".ANALYTICA CHIMICA ACTA 602.2(2007):252-258.
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