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trans-(1R,2R)-diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase
Zhu, Guiru; Jiang, Dongmei; Yang, Qihua; Yang, Jie; Li, Can
KeywordBifunctionalized Mesoporous Organosilica Spheres Ligand Exchange Traps-(1r Chiral Stationary Phase 2r)-diaminocyclohexane Hplc
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2007-05-18
DOI10.1016/j.chroma.2007.03.011
Volume1149Issue:2Pages:219-227
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; LIGAND-EXCHANGE CHROMATOGRAPHY ; LARGE-PORE ; ORGANIC FUNCTIONALITY ; SILICA SPHERES ; CHANNEL WALLS ; HPLC ; SEPARATION ; MORPHOLOGY ; SURFACTANT
AbstractThe bifunctionalized mesoporous organosilica spheres with trans-(1R,2R)-diaminocyclohexane (DACH) in the pore were synthesized and their application as chiral stationary phase in high-performance liquid chromatography (HPLC) was demonstrated. Bifunctionalized mesoporous organosilica spheres with narrow particle size distribution of 5-7 mu m were prepared by the co-condensation of N-[3-(triethoxysilyl)propyl]-trans(1R,2R)-diaminocyclohexane (M(propyl)) with 1,2-bis(trimethoxysilyl)ethane (BTME) in basic medium using octadecyltrimethyl ammonium chloride (C(18)TAC1) as structural directing agent and ethanol as co-solvent. The morphologies of the bifunctionalized mesoporous organosilicas were sensitive to the molar fraction of M(propyl). At higher M(propyl)/BTME molar ratio, the bifunctionalized organosilica spheres with ordered mesoporous structure can be formed in a wide range of synthetic conditions. When the molar percent of M(propyl)/(M(propyl)/BTME) is less than 20, the formation of spheres could be hardly observed. The structural order of the materials mainly depends on the base concentration and Mpropyi/BTME molar ratio in the initial sol mixture. A column packed with the bifunctionalized mesoporous organosilica spheres exhibits higher selectivity and resolution for racemic amino acids than that packed with DACH-SiO(2) prepared by conventional post-synthesis grafting method. (c) 2007 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000246673000010
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140418
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Guiru,Jiang, Dongmei,Yang, Qihua,et al. trans-(1R,2R)-diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase[J]. JOURNAL OF CHROMATOGRAPHY A,2007,1149(2):219-227.
APA Zhu, Guiru,Jiang, Dongmei,Yang, Qihua,Yang, Jie,&Li, Can.(2007).trans-(1R,2R)-diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase.JOURNAL OF CHROMATOGRAPHY A,1149(2),219-227.
MLA Zhu, Guiru,et al."trans-(1R,2R)-diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase".JOURNAL OF CHROMATOGRAPHY A 1149.2(2007):219-227.
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