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题名: trans-(1R,2R)-diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase
作者: Zhu, Guiru;  Jiang, Dongmei;  Yang, Qihua;  Yang, Jie;  Li, Can
关键词: bifunctionalized mesoporous organosilica ;  spheres ;  traps-(1R,2R)-diaminocyclohexane ;  ligand exchange ;  chiral stationary phase ;  HPLC
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2007-05-18
DOI: 10.1016/j.chroma.2007.03.011
卷: 1149, 期:2, 页:219-227
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The bifunctionalized mesoporous organosilica spheres with trans-(1R,2R)-diaminocyclohexane (DACH) in the pore were synthesized and their application as chiral stationary phase in high-performance liquid chromatography (HPLC) was demonstrated. Bifunctionalized mesoporous organosilica spheres with narrow particle size distribution of 5-7 mu m were prepared by the co-condensation of N-[3-(triethoxysilyl)propyl]-trans(1R,2R)-diaminocyclohexane (M(propyl)) with 1,2-bis(trimethoxysilyl)ethane (BTME) in basic medium using octadecyltrimethyl ammonium chloride (C(18)TAC1) as structural directing agent and ethanol as co-solvent. The morphologies of the bifunctionalized mesoporous organosilicas were sensitive to the molar fraction of M(propyl). At higher M(propyl)/BTME molar ratio, the bifunctionalized organosilica spheres with ordered mesoporous structure can be formed in a wide range of synthetic conditions. When the molar percent of M(propyl)/(M(propyl)/BTME) is less than 20, the formation of spheres could be hardly observed. The structural order of the materials mainly depends on the base concentration and Mpropyi/BTME molar ratio in the initial sol mixture. A column packed with the bifunctionalized mesoporous organosilica spheres exhibits higher selectivity and resolution for racemic amino acids than that packed with DACH-SiO(2) prepared by conventional post-synthesis grafting method. (c) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  LIGAND-EXCHANGE CHROMATOGRAPHY ;  LARGE-PORE ;  ORGANIC FUNCTIONALITY ;  SILICA SPHERES ;  CHANNEL WALLS ;  HPLC ;  SEPARATION ;  MORPHOLOGY ;  SURFACTANT
语种: 英语
WOS记录号: WOS:000246673000010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140418
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Zhu, Guiru,Jiang, Dongmei,Yang, Qihua,et al. trans-(1R,2R)-diaminocyclohexane-functionalized mesoporous organosilica spheres as chiral stationary phase[J]. JOURNAL OF CHROMATOGRAPHY A,2007,1149(2):219-227.
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