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Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods
Su, Xingye; Qin, Feng; Kong, Liang; Ou, Junjie; Xie, Chuanhui; Zou, Hanfa
关键词Tetrahydropalmatine Enantioselectivity Dna Binding Natural Products Chromatographic Methods
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2007
DOI10.1016/j.jchromb.2006.07.050
845期:1页:174-179
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; AFFINITY-CHROMATOGRAPHY ; PROTEIN INTERACTIONS ; METAL-COMPLEXES ; TOPOISOMERASE-I ; MICRODIALYSIS ; ALKALOIDS ; LIGANDS ; PHASES ; HPLC
英文摘要A racemate from natural product, tetrahydropalmatine (THP), was characterized on its enantioselective binding to DNA by the chromatographic methods including microdialysis/HPLC, centrifugal ultrifiltration/HPLC and immobilized DNA affinity chromatography. It was found that its (+)-enantiomer was preferential to binding on B-form duplex DNA including calf thymus DNA, AT and GC sequence oligo DNA, as well as triplex oligo DNA. The binding constants of the THP enantiomers to ct-DNA were determined with the methods of microdialysis/HPLC and frontal affinity chromatography. In addition, the DNA structural preference of either enantiomer was evaluated with the chromatographic methods. (c) 2006 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000243704200021
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/140426
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
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Su, Xingye,Qin, Feng,Kong, Liang,et al. Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2007,845(1):174-179.
APA Su, Xingye,Qin, Feng,Kong, Liang,Ou, Junjie,Xie, Chuanhui,&Zou, Hanfa.(2007).Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,845(1),174-179.
MLA Su, Xingye,et al."Characterization of enantio selective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 845.1(2007):174-179.
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