中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells
作者: Cao, Jun;  Jiang, Li-Ping;  Liu, Yong;  Yang, Guang;  Yao, Xiao-Feng;  Zhong, Lai-Fu
关键词: curcumin ;  genotoxicity ;  antigenotoxicity ;  HepG2 cells ;  cyclophosphamide
刊名: TOXICON
发表日期: 2007-06-15
DOI: 10.1016/j.toxicon.2007.02.006
卷: 49, 期:8, 页:1219-1222
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: Curcumin, a polyphenolic yellow pigment found in turmeric, is commonly used as a coloring agent in foods, drugs, and cosmetics. In our previous study, we found that low levels of curcumin did not increase the reactive oxygen species (ROS) formation and caused no damage to DNA in human hepatoma G2 (HepG2) cells, but at high doses, curcumin imposed oxidative stress and damaged DNA. In the present study, we are determined to investigate the genotoxic and antigenotoxic effects of curcumin using HepG2 cell line, a relevant in vitro model to detect the cytoprotective, antigenotoxic, and cogenotoxic agents. The results of micronucleus (MN) assays showed that, on one hand, curcumin at the high tested concentrations (8 and 16 mu g/ml) displayed a small but significant increase in the frequency of MN, and on the other hand, it was observed that the low tested concentration (2 mu g/ml) significantly reduced the MN formation induced by the chemotherapeutic agent cyclophosphamide. The present results indicate that curcumin shows both genotoxicity and anti genotoxicity depending on its concentration. (c) 2007 Elsevier Ltd. All rights reserved.
关键词[WOS]: HAMSTER OVARY CELLS ;  INDUCED CHROMOSOME-ABERRATIONS ;  CULTURED-MAMMALIAN-CELLS ;  IN-VIVO ;  DAMAGE ;  AGENTS ;  VITRO
语种: 英语
WOS记录号: WOS:000247711400018
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140471
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Dalian Med Univ, Dept Toxicol, Dalian 116027, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Cao, Jun,Jiang, Li-Ping,Liu, Yong,et al. Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells[J]. TOXICON,2007,49(8):1219-1222.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Cao, Jun]'s Articles
 [Jiang, Li-Ping]'s Articles
 [Liu, Yong]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Cao, Jun]‘s Articles
 [Jiang, Li-Ping]‘s Articles
 [Liu, Yong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace