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题名: Nanoliter-scale etched capillary electrospray interface of mass spectrometry
作者: Duan Ji-Cheng;  Liu He-Chun;  Liang Zhen;  Zhang Wei-Bing;  Zhang Li-Hua;  Zhang Yu-Kui
关键词: mass spectrometry ;  electrospray interface ;  HF etching ;  protein detection
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2007-01-10
卷: 28, 期:1, 页:29-33
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: A nanoliter-scale electrospray interface for mass spectrometry was developed by modifying the commercial sheathflow interface for capillary electrophoresis coupling with mass spectrometry(CE-MS). The interface was fabricated by using HF etching on a 50 mu m i. d. fused-silica capillary. The outer wall of the. interface was shown a porous structure, and its thickness was as thin as about 10 mu m. A protein sample, cytochrome c., was analyzed by using the etched interface at. the volumetric flow rate as low. as 20 nL/min., The influence of contacting electrolyte between the etched capillary and the stainless steel sheath tube on ESI was investigated and explained. The comparative study of electrospray performance of the commercial micro stainless steel interface and the etched one was carried out by using protein as sample. The higher response signal was achieved by using the modified interface in the flow rate range of 50-500 nL/min. The sensitivity of detection was increased 3.6 times at the flow rate of 200 nL/min compared with the commercial micro interface.
关键词[WOS]: SHEATHLESS CAPILLARY ;  ZONE-ELECTROPHORESIS ;  IONIZATION ;  PROTEIN ;  PERFORMANCE
语种: 英语
WOS记录号: WOS:000243581800007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/140542
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Duan Ji-Cheng,Liu He-Chun,Liang Zhen,et al. Nanoliter-scale etched capillary electrospray interface of mass spectrometry[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(1):29-33.
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