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Nanoliter-scale etched capillary electrospray interface of mass spectrometry
Duan Ji-Cheng; Liu He-Chun; Liang Zhen; Zhang Wei-Bing; Zhang Li-Hua; Zhang Yu-Kui
KeywordMass Spectrometry Electrospray Interface Hf Etching Protein Detection
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2007-01-10
Volume28Issue:1Pages:29-33
Indexed BySCI
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordSHEATHLESS CAPILLARY ; ZONE-ELECTROPHORESIS ; IONIZATION ; PROTEIN ; PERFORMANCE
AbstractA nanoliter-scale electrospray interface for mass spectrometry was developed by modifying the commercial sheathflow interface for capillary electrophoresis coupling with mass spectrometry(CE-MS). The interface was fabricated by using HF etching on a 50 mu m i. d. fused-silica capillary. The outer wall of the. interface was shown a porous structure, and its thickness was as thin as about 10 mu m. A protein sample, cytochrome c., was analyzed by using the etched interface at. the volumetric flow rate as low. as 20 nL/min., The influence of contacting electrolyte between the etched capillary and the stainless steel sheath tube on ESI was investigated and explained. The comparative study of electrospray performance of the commercial micro stainless steel interface and the etched one was carried out by using protein as sample. The higher response signal was achieved by using the modified interface in the flow rate range of 50-500 nL/min. The sensitivity of detection was increased 3.6 times at the flow rate of 200 nL/min compared with the commercial micro interface.
Language英语
WOS IDWOS:000243581800007
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/140542
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Duan Ji-Cheng,Liu He-Chun,Liang Zhen,et al. Nanoliter-scale etched capillary electrospray interface of mass spectrometry[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(1):29-33.
APA Duan Ji-Cheng,Liu He-Chun,Liang Zhen,Zhang Wei-Bing,Zhang Li-Hua,&Zhang Yu-Kui.(2007).Nanoliter-scale etched capillary electrospray interface of mass spectrometry.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,28(1),29-33.
MLA Duan Ji-Cheng,et al."Nanoliter-scale etched capillary electrospray interface of mass spectrometry".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 28.1(2007):29-33.
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